Biological Sciences : Therapeutics Treatment of Donor Allografts to Prevent Recurrent Hepatitis C Virus Infection after Liver Transplant (JHU ref. C10397) Hepatitis C Virus (HCV) infects 4 million Americans and 170 million worldwide. It is currently the number ... More...   Imaging and Radiotherapy of Malaria Infection (JHU ref. C10607) JHU scientists have proposed a novel malaria parasite specific positron emission tomography (PET) imaging ... More...   A Component of Ginseng Arrived By Total Chemical Synthesis Potently Induces Cancer Chemoprotective and Antioxidant Phase 2 Enzymes (JHU ref. C10126) JHU researchers have assayed ginseng (PANAX spp.) extracts and components for inducer activity of NQO1 ... More...   Novel drug target to prevent and reduce atherosclerosis (JHU ref. C10540) Cardiovascular disease remains a global public health problem. A leading cause of cardiovascular disease ... More...   A novel target for drug and cell-based therapy to prevent and treat radiation disorders (JHU ref. C10542) Radiation injury can occur from external irradiation either total body irradiation or partial body irradiation ... More...   Treatment of Epidermolysis Bullosa Simplex and Related Skin Diseases (JHU ref. C10069) Epidermolysis bullosa is a disorder characterized by the presence of extremely fragile skin, which loses ... More...   Isoprenoid Pathway Inhibitors and Assays (JHU Ref. C10727 & C10728) (JHU ref. C10727) BACKGROUND Isoprenoids are a large and diverse class of naturally-occurring organic chemical compounds ... More...   Treatment of Epidermolysis Bullosa Simplex and Related Skin Diseases (JHU ref. C10069) Epidermolysis bullosa is a disorder characterized by the presence of extremely fragile skin, which loses ... More...   MicroRNA & Nucleotide Delivery System to Treat Liver Cancer (JHU ref. C10568) BACKGROUND Over 500,000 people are diagnosed with liver cancer worldwide each year. According the ... More...   High Affinity Small Molecule Inhibitors of Hepatitis C NS3/4A Protease (JHU ref. C10622) BACKGROUND An estimated 150-200 million people worldwide are infected with hepatitis C. Hepatitis ... More...   Global Genetic Alterations Analysis & Novel Diagnostic/Therapeutic Biomarkers for Breast and Colorectal Cancer (JHU ref. C10471) BACKGROUND It is well accepted that cancer is the result of the sequential mutations of oncogenes ... More...   Molecular Target to Diagnose & Treat Pancreatic Cancer & Methods to Identify New Targets (JHU ref. C10569) BACKGROUND Pancreatic cancer is a malignant tumor of the pancreas. Each year ~250,000 people worldwide ... More...   Treatment of Chronic Rhinosinusitis (JHU ref. C10433) Each year, chronic rhinosinusitis (CRS) affects approximately 15% of the United States population or ... More...   Soluble Self-Assembling Peptides for Organic Electronics  (JHU ref. C10556) BACKGROUND Self-assembling supramolecular objects with pi-electron functionality are of increasing ... More...   L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection (JHU ref. C10218) Human papillomavirus (HPV) infections are the most common sexually transmitted infection in the United ... More...   Identification of immune regulatory targets in ovarian cancer (JHU ref. C10565) Ovarian cancer ranks fifth highest as the cause of cancer-related deaths among females and has the highest ... More...   Novel Biomarkers and Therapeutic Targets for Melanoma (JHU ref. C10223) Melanoma is a potentially life-threatening form of skin cancer whose incidence is increasing at the ... More...   A Nutraceutical Treatment for Parkinson's Disease (JHU ref. C10578) Aggregation of a protein known as alpha-synuclein in cells is a key factor in the pathogenesis of Parkinson’s ... More...   Leucine rich repeat kinase 2 (LRRK2)- mediated Neuronal Toxicity (JHU ref. C10581) Parkinson’s disease (PD), a common neurodegenerative movement disorder. Recent discovery of specific ... More...   Direct Delivery Method of 3- Bromopyruvate, a Potent Therapy for Liver Cancer (JHU ref. C03939) Liver cancer is one of the most common fatal cancers in the world and may reach epidemic levels in ... More...   Novel Epigenomic Biomarkers for Breast Cancer (JHU ref. C10643) BACKGROUND: Breast cancer is the leading cause of cancer death among women worldwide. According ... More...   Cryoimmunotherapy of Advanced Cancer (JHU ref. C10623) Cancer is projected to become the leading cause of death worldwide in the year 2010. The newest projected ... More...   Hyperactive Transposons for Transgenesis and Functional Genomics Studies in Mammals (JHU Ref. C10599, C10611, C10612) (JHU ref. C10599) BACKGROUND: Transposons are sequences of DNA that can move around the genome of a single cell in ... More...   Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus (JHU ref. C04832) Clavulanic acid is a potent beta-lactamase inhibitor used to combat resistance to penicillin and cephalosporin ... More...   Serum-based assay for prostate cancer detection (JHU ref. C10443) Prostate cancer is the second leading cause of cancer death in men in the United States. The currently ... More...   Implantable Multilayer 3D Scaffold for Neuronal Regeneration (JHU ref. C10716) Spinal Cord Injury (SCI) can result in catastrophic loss of function. In the US, ~ 450,000 people live ... More...   New indication for an FDA-approved drug – prostate cancer prevention (JHU ref. C10649) According to the American Cancer Society, nearly 190,000 men are diagnosed with prostate cancer each ... More...   Chlamydia vaccine (JHU ref. C09816) According to the World Health Organization, approximately 92 million new cases of Chlamydia trachomatis ... More...   Chemotherapeutic Agents to Treat and Prevent Cutaneous Squamous Cell Carcinoma (JHU ref. C10620) Cutaneous squamous cell carcinoma (SCC) is the second most common type of skin cancer. More than 1 million ... More...   Treatment of Autism Spectrum Disorders with a Dietary Supplement (JHU ref. C10705) Autism is a complex developmental disability caused by neurological issues. It affects 1 in every 150 ... More...   FDA approved drug enhances the DNA vaccine potency to control HPV-associated malignancies (JHU ref. C10371) The majority (98%) of all cervical cancers are the result of human papillomavirus infection (HPV). According ... More...   Monoclonal antibodies in combination with DNA vaccine enhance therapeutic anti-tumor effects (JHU ref. C10372) Human papillomavirus (HPV) infection causes 98% of all cervical cancers. About 20 million Americans ... More...   Low-dose radiation enhances therapeutic HPV DNA vaccination (JHU ref. C10373) Human papillomavirus (HPV) infection causes 98% of all cervical cancers. About 20 million Americans ... More...   Genetic Biomarkers for Prognosis of Acute Lung Injury Patient Outcome (JHU ref. C10423) Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), a more severe form of ALI are ... More...   The most effective method of HPV DNA vaccine administration (JHU ref. C10597) One of the methods to protect an organism against the diseases is DNA vaccination, where genetically ... More...   Screening Method to Identify Effective Chemotherapy Drugs with Fewer Unwanted Side Effects (JHU ref. c05044) The goals of cancer treatment are to reduce tumor cell growth and to kill existing cancerous ... More...   Novel human embryonic pluripotent germ cell line, methods of producing and application (JHU ref. C03127) JHU scientists provide a human EG cell line and methods of producing such cells in vitro. They also ... More...   The Direction of Controlled Heat Specifically to Cancer Cells to Enhance Therapeutic Responses to Combination Therapy (JHU ref. C05010) The novel featues outlined in ths invention are: 1. The use of localized limited heat that is specifically ... More...   Peptide Based Inhibitors of PSA (JHU ref. C10238) Prostate cancer is the leading cancer for men in the United States, accounting for 25% of all new cancer ... More...   New PSMA-targeting reagent for SPECT imaging (JHU ref. C10635) JHU scientists have synthesized a new prostate-specific membrane antigen (PSMA) targeting reagent for ... More...   New PSMA-targeting reagent for PET imaging (JHU ref. C10636) JHU scientists have synthesized a new prostate-specific membrane antigen (PSMA) targeting reagent for ... More...   Improvement of the Efficacy of Stem Cell Therapy (JHU ref. C10541) Currently there are no effective therapies to prevent or treat inflammatory disorders that includes ... More...   Complement Factor Expression Linked to Susceptibility to Flavivirus Infections (JHU ref. C10625) Dengue fever is an acute insect-borne viral disease that can worsen into life-threatening dengue hemorrhagic ... More...   New Glaucoma Pathology Similarities to Parkinson’s Disease and Synuclein Polyclonal Antibody useful for Glaucoma Research (JHU ref. C10626) Glaucoma is a group of progressive eye diseases that are the second leading cause of blindness worldwide. ... More...   Small Molecule to treat chronic inflammatory diseases and cancer (JHU ref. C10319) Lung cancer is the leading cause of cancer death in the United States. Novel chemopreventive agents ... More...   Modulating Notch Signaling Pathway to Control the Cell Fate Determination of Human Pluripotent Stem Cells (JHU ref. C10379) During embryonic development and adult life the Notch signaling pathway plays important roles in cell-fate ... More...   Development of Novel Agents that Promote Axonal Regeneration to Potentially Treat CNS Injury and Parkinson’s disease (JHU ref. C10369) In the mature mammalian central nervous system (CNS), the ability of axons to regenerate after injury ... More...   A Small Molecule Inhibitor of Glioblastomas (JHU ref. C10047) BACKGROUND: Mutations of the epidermal growth factor receptor (EGFR) are a possible molecular target ... More...   Toxic Role of Heme Oxygenase in Hemorrhage (JHU ref. C05149) JHU scientists have investigated the contribution of inducible HO-1 to early brain injury produced by ... More...   Novel Agents for the Prevention and Treatment of Inflammation-Related Vascular Thrombotic Disorders (JHU ref. C05005) Inflammation is known to be an integral part of the vascular occlusive events that occur during heart ... More...   Glutaminase Inhibition to Treat Cancer, Cardiac Ischemia and Stoke (JHU ref. C10460) A common occurrence in cancer is altered glucose metabolism where cells take up glucose avidly and convert ... More...   Selective Prodrug Activation in Cancer Cells Using Protein Switches (JHU ref. C10450) Cancer is a major health problem in the world and is the second leading cause of death in the U.S. ... More...   Targeted genome engineering in mammalian cells and plants using custom-designed Zinc Finger Nucleases (ZFNs) (JHU ref. C04775) Johns Hopkins researchers have designed and engineered a new generation of Zinc Finger Nucleases (ZFNs) ... More...   Collagen Mimetic Peptides for Imaging and Therapy (JHU ref. C10462) Collagens, the most abundant protein in mammals, provide a structural framework during tissue development ... More...   Methods of Generating Primate Pluripotent Stem Cells from Non-Embryonic Sources (JHU ref. C10400) Currently, the efficiency of generating human induced pluripotent stem (iPS) cells is low. JHU scientists ... More...   Treatment of Retinal Degenerations with Gene Transfer of Components of the Anti-oxident Defense System (JHU ref. C10387) In age-related macular degeneration (AMD), rods, cones, and retinal pigmented epithelial (RPE) cells ... More...   A Malaria Vaccine to Stop Malaria Transmission (JHU ref. C10497) Malaria is a disease caused by parasites of the genus Plasmodium. It affects near 2 billion people worldwide ... More...   Embogel/Emboclear Therapeutic Solution – A Dissolvable Radio-Opaque Alginate-Based Biomaterial For Endovascular Delivery And Controlled Therapeutic Agent Release (JHU ref. C05004) EmboCaps consist of an alginate matrix with controllable porosity that provides a means of diffusion-controlled ... More...   Biomarkers for Pancreatic and Biliary Cancers (JHU ref. C10090) Pancreatic and biliary cancers are two of the most fatal among all human malignancies. Late presentation ... More...   Radiolabeled Inhibitors for Prostate Cancer Imaging & Therapeutics (JHU ref. C10098) Prostate-specific membrane antigen (PSMA) is a cell surface protein that is over expressed in prostate ... More...   A Novel Cystic Fibrosis Therapeutic Agent (JHU ref. C10156) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- ... More...   Method of Inhibiting Parasitic Activity (JHU ref. C09861) A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function ... More...   Novel Inhibitors of CRAC Channel As Immunosuppressants (JHU ref. C05046) T cell activation is essential for immune response. It is primarily responsible for graft rejection ... More...   Methods and Compositions for Treatement of Intraepithelial Neoplasia (JHU ref. C04560) The present invention provides for compositions, kits and methods for treatment of intraepithelial neoplasia, ... More...   Treatment for Ischemia Tissue Damage by Modulating T-Cell Number and Activity.  (JHU ref. C03931) Johns Hopkins University is currently seeking licensees for a therapeutic technology for ischemia. ... More...   A Parkinson's Disease Cell Model and Therapeutic Target (JHU ref. C10486) Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by selective ... More...   Modulation of Regulatory T cell (Treg) Function (JHU ref. C10323) Regulatory T cells (Treg) are a subset of the CD4 T cell population that down-modulate an immune response. ... More...   Diagnostic and Prognostic Markers and Treatment Strategies for Multiple Sclerosis (JHU ref. C04371) To date, there are no definitive biomarkers to assist clinicians in the diagnosis of multiple sclerosis ... More...   A Bacteriostatic Antibiotic has Neuroprotective Effect in a Gliosarcoma Tumor Model (JHU ref. C10257) Malignant gliomas are the most common type of primary brain tumors affecting about 16,000 new patients ... More...   Prevention and Treatment of Bacterial and Fungal Meningitis  (JHU ref. C10349) Johns Hopkins University is currently seeking licensees for a method of preventing meningitis caused ... More...   Augmentation of Endocardial Thromboresistance (JHU ref. c04927) A critical function of the endocardium is to maintain local thromboresistance by providing an anticoagulant ... More...   Known Drug found to have applicability in the area of glaucoma, optic nerve diseases, and other neurodegenerations (JHU ref. C10454) According to the World Health Organization, glaucoma is the second leading cause of blindness in the ... More...   Methods To Reduce Damage From Stroke And Other Neurological Disorders. (JHU ref. C10149) Cerebral ischemia (stoke) is an acute neurological condition that is caused by a blood clot that blocks ... More...   Floxed GFRalpha-1 Mouse (JHU ref. C10008) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation ... More...   Floxed Ret Mouse (JHU ref. c10009) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation ... More...   Cystic Fibrosis bronchial epithelial cell line S9 (JHU ref. C04772) Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 ... More...   Breast Milk Component Provides Protection Against Acute Respiratory Diseases (JHU ref. C10062) It has long been established that breast milk provides a protective role against acute respiratory disease. ... More...   Therapeutic target for treatment of Alzheimer's Disease, Down's syndrome, and fragile X mental retardation syndrome (JHU ref. C10383) JHU scientists have identified a therapeutic target that mediates rapid synthesis of proteins essential ... More...   Small molecule as Novel Anti-tumor and Anti-angiogenic Agent (JHU ref. C10200) JHU scientists found that a known antibiotic inhibits the type 2 methionine aminopeptidase and possesses ... More...   MicroRNA Enhancement and Inhibition of Astroglial Glutamate Transporter  (JHU ref. C10255) JHU inventors have identified a population of microRNA (miRNA) associated with a critical neurotransmitter ... More...   Determinants of ShhN required for signaling (JHU ref. C03764) The invention relates to hedgehog proteins that are involved in signaling developmental processes. The ... More...   Large-scale Survival, Differentiation and Structural Integration of Human Neural Stem Cells Grafted into the Adult (JHU ref. C04699) The present invention provides methods and compositions for treating spinal cord diseases and injuries. ... More...   Ligands for Nicotinice Acetylcholine Receptors, and Methods of Making and Using Them (JHU ref. C05022) One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic ... More...   The Immediate Early Gene Arc Interacts with Endocytic Machinery and Regulates the Trafficking and Function of Presenilin (JHU ref. C10190) These discoveries promise a novel approach to develop agents to regulate presenilin 1 (PS 1) and treat ... More...   A "Molecular Switch" in Group 1 mGluR Signaling Relevant to Neurological and Psychiatric Diseases (JHU ref. C10191) Reported here is the mechanism by which group 1 metabotropic glutamate receptors (mGluR) are co-functional ... More...   A Novel Cystic Fibrosis Therapeutic Agent (JHU ref. C10145) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- ... More...   A Novel Cystic Fibrosis Therapeutic Agent (JHU ref. C10156) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- ... More...   Gene Responsible for Stargardt-like Dominant Macular Dystrophy (JHU ref. C03716) The gene responsible for Stargardt-like macular dystrophy has been identified, along with its normal ... More...   Homer Regulates Cellular Calcium Signaling: A Novel Target for Pharmaceutical Development (JHU ref. C03447) A method is provided for identifying a compound that modulates a cellular response associated with Homer ... More...   Control of Human mesothelin-expressing tumors by DNA vaccines (JHU ref. C10013) Mesothelin has been implicated as a potential ideal target antigen for the development of antigen-specific ... More...   Diagnosis, Prevention and Treatment of Eye Injury and Infection (JHU ref. C10102) According to the World Health Organization, cataracts are the leading cause of blindness in the world. ... More...   Diagnostic, Prognostic, and Therapeutic Biomarkers for Heart Injury, Cardiac Stem Cell Regeneration, and the Facilitation of Patient Recovery  (JHU ref. C10224) Stem cells hold the promise to revolutionize future reparative medicine through the development of stem ... More...   Inhibiting Binding of Inducible Nitric Oxide Synthase to Cyclooxygenase-2 to Treat Inflammation (JHU ref. C04667) Cyclooxygenase (C0X2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. ... More...   System For Refibrillation of the Heart For Treatment of Post Countershock Pulseless Electrical Activity and Asystole (JHU ref. C03941) A method and/or system for inducing ventricular fibrillation (VF) of the heart for treatment of post-countershock ... More...   BDNF Polymorphism and Association with Bipolar Disorder (JHU ref. C03869) Johns Hopkins University scientists have determine diagnostic and therapeutic methods for neuropsychiatric ... More...   Gastric Reduction Endoscopy (JHU ref. C03634) This technology comprises methods and devices for partitioning or plicating a region of a hollow body ... More...   Transgastric Peritoneoscopy (JHU ref. C03634) JHU scientists have developed a novel approach to diagnostic and therapeutic interventions in the peritoneal ... More...   Association of Dopamine Beta-Hydroxylase Polymorphisms with Bipolar Disorder (JHU ref. C03911) A central role for the gene encoding dopamine beta-hydroxylase in neuropsychiatric disorders has been ... More...   A Set of Novel Immediate Early Genes from Brain (JHU ref. C03369) The present invention provides methods and materials related to immediate early genes. Specifically, ... More...   Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders (JHU ref. C10150) An acute neurological condition caused by blood clots that block blood vessels in the brain is cerebral ... More...   Methods to reduce damage from stroke and other neurological disorders. (JHU ref. C10149) Cerebral ischemia (stoke) is an acute neurological condition that is caused by a blood clot that blocks ... More...   Variant Gene Increases Risk of Type 2 Diabetes (JHU ref. C10068) Type II Diabetes Mellitus (T2DM) represents a major global health challenge with over 170 million people ... More...   Breast Milk Component Provides Protection Against Acute Respiratory Diseases (JHU ref. C10062) It has long been established that breast milk provides a protective role against acute respiratory disease. ... More...   New Therapeutic Uses for Camptothecin Analogs (JHU ref. C09727) JHU scientist have discovered that camptothecin compounds are effective inhibitors of hemoflagellate growth. More...   Human BARX2 Gene (JHU ref. C03545) JHU scientists have discovered that the gene encoding BarH-like homeobox 2 protein (Barx2) is unexpectedly mutated in ovarian cancer. More...   Kidney Derived Stem Cells Modulate Immune Response To Acute Kidney Injury (JHU ref. C10202) Recent data has suggested that stem cells, such as mesenchymal cells derived from bone marrow, demonstrate ... More...   Chronic Neuropathic Pain Relief with Reduced Side Effects (JHU ref. C10182) Overview Johns Hopkins University is actively seeking licensees for an improved method of administering ... More...   Method of Synthesis of Chemospheres and Chemogel, Hydrogel Embolic Particles and Gel for Locoregional Delivery of Therapeutic Agents and Immunoisolation of Cellular Therapeutics (JHU ref. C10201) JHU scientists have developed a method of producing innovative biocompatible compositions useful for ... More...   Use of Transcranial Magnetic Stimulation (TMS) to Treat Cerebral Palsy. (JHU ref. C10095) Cerebral palsy is manifested in a wide range of muscle dysfunctions which can have a severe impact on ... More...   Combination device and solution for efficient removal of insect from the ear canal (JHU ref. C10391) The innovative dual-action solution contains an enzyme specific for an insect exoskeleton protein and ... More...   Combinational Paradigm Combating HIV, HIV/HSV or HIV/HPV Infections in Humans (JHU ref. C05144) WHO report has stated that there are 39.5 million people currently HIV positive worldwide. Of these, ... More...   Diagnosis and Treatment of Cardiac Allograft Vasculopathy with Uric Acid Levels and Enzymatic Inhibitors  (JHU ref. C04738) JHU scientists have developed a method to predict and prevent a condition that is a serious complication ... More...   Novel Chimeric Transmembrane Proteins with Non-mammalian Cell Surface Domains (JHU ref. C10142) JHU scientists have generated novel human type II transmembrane based proteins that are designed for ... More...   Ras-regulated microRNAs as a novel anti-cancer therapeutic strategy (JHU ref. C10236) MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency ... More...   Molecular Insights into Breast Cancer Prevention and Therapeutics Involving Novel Genistein Analogs (JHU ref. C10280) Cancer is the second leading cause of death in the U.S. and claims the lives of around 555,000 Americans ... More...   Spinal Vertebral Interventions by Natural Orifice Translumenal Endoscopic Surgery (NOTES) (JHU ref. C10333) Vertebral spine procedures are currently performed via thoracoscopy and other percutaneous approaches. ... More...   Rapid Induction of Cancer Cell Death by Synergistic Treatment of Tetra-O-methyl Nordihydroguaiaretic Acid (M4N) with either Two Specific Kinase Inhibitors (JHU ref. C10281) M4N is an anti-cancer drug candidate, which is currently under the first phase of clinical trials. Although ... More...   Cancer Immunotherapy Using Irradiated Tumor Cells Secreting Hsp 70 (JHU ref. C10303) Ovarian cancer is responsible for the highest mortality rate among patients with gynecologic malignancies. ... More...   Carcinoembryonic Antigen as a Potential Biomarker for use in Targeted Drug Delivery Applications as well as Other Therapeutic Strategies (JHU ref. C10320 ) Blood-borne metastasis is a highly regulated and dynamic process, whereby cancerous cells separate from ... More...   Hybridoma RG-1 (JHU ref. C10337) JHU scientists generated a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and ... More...   Anopheles Gambiae Densonucleosis Virus Expression System (JHU ref. C10345 ) Densonucleosis viruses (DNVs) are single-stranded non-enveloped viruses in the family parvoviridae. ... More...   Potential Biomarker for Use in Targeted Drug Delivery Applications As Well As Other Therapeutic Strategies (JHU ref. C10350 ) According to the World Health Organization (WHO), malignant tumors accounted for around 12% of deaths ... More...   High Therapeutic Promise of Dually Targeting the PI3K/Akt and MAP Kinase Pathways in Poorly Differentiated and Undifferentiated Thyroid Cancer Cells (JHU ref. C10292) Poorly differentiated and undifferentiated thyroid cancers have impaired or no response to the conventional ... More...   Beta-3 Adrenergic Receptor Agonists Reduce Cardiac Hypertrophy and Heart Failure (JHU ref. C10301) This invention is based on the discovery of a novel role for beta-3 adrenergic receptors (B3AR) in the ... More...   Monoamine oxidase (MAO) inhibitors reduce cardiac hypertrophy and prevent heart failure (JHU ref. C10311) JHU scientists have developed a method to reduce heart muscle cell changes that lead to heart enlargement ... More...   High Affinity Small Molecule Inhibitors of Hepatitis C NS3/4A Protease (JHU ref. C10310) Hepatitis C virus (HCV) infection is a growing global health problem with over 3 million new cases of ... More...   Methods to Associate and Immobilize Viruses to Mucus (JHU ref. C10315) JHU scientists have discovered a new way to reduce the spread of viral infections by minimizing virus ... More...   Methods to Reduce Mesh Spacing of the Protective Mucus Barrier (JHU ref. C10264) Human mucus forms a protective barrier to toxins and infectious pathogens on all the most susceptible ... More...   Tumor Suppressor MicroRNAs Controlling Cancer Cell Growth (JHU ref. C10245) Johns Hopkins scientists have discovered two microRNAs that are expressed in normal blood cells, but ... More...   Novel Immunotherapy for Contact Dermatitis (JHU ref. C10168) Allergic contact dermatitis, the third most common reason for outpatient dermatology visits, is an immunological ... More...   Candidate Proteasome Inhibitors that Prevent E6 Mediated p53 Degradation and Selectively Kill HPV+ Cervical Cancer (JHU ref. C10163) High-risk strains of Human papillomavirus (HPV) cause over 90% of cervical cancers. About 20 million ... More...   A Novel Therapeutic and Diagnostic Modality in Human Cancer (JHU ref. C10107) Epithelial cancers (carcinomas) make up approximately 85% of all cancers and utilize a variety of strategies ... More...   Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity (JHU ref. C10100) A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing ... More...   Seventy Two Gene Model for 8 Thyroid Tumor Types (JHU ref. C10073) Thyroid cancer represents 90% of all neuroendocrine malignancies with an estimated annual incidence ... More...   Novel Calcitriol Analogs (JHU ref. C10051) Five to eight million people in the US and 125 million people worldwide have psoriasis. Current treatment ... More...   Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic Treatment (JHU ref. C10039) Targeted tumor therapy is commonly based on the use of antibodies directed against a specific molecule, ... More...   A New Tumor Suppressor Gene (JHU ref. C09856) A new tumor suppressor gene, HIC-1, has been found. Abnormal DNA methylation of a CpG island, which ... More...   Invention Relating to Prostatic Cancer (JHU ref. C09797) The isolation and characterization of a metastasis tumor suppressor gene KAI1 is disclosed and diagnostic ... More...   Reversal of Aberrant Cancer Gene Silencing By Inhibition of SIRT1 (JHU ref. C05108) The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in ... More...   Use of High-dose Oxazaphosphorine Drugs in Combination with Monoclonal Antibodies for Treating Immune Disorders (JHU ref. C05098) Autoimmune diseases afflict more than 8 million people in the U.S alone. Autoimmunity usually occurs ... More...   Use of High Dose Cyclophosphamide in Combination with Anti-Idiotypic Vaccines in Anti-cancer Therapy (JHU ref. C05073) Recently, immunotherapy based techniques have been developed for the treatment of various cancers. The ... More...   Use of High Dose Cyclophosphamide in Combination with Immune Therapeutics in Anti-Cancer Therapy (JHU ref. C05072) Cyclophosphamide and especially high-dose cyclophosphamide has been used for the treatment of certain ... More...   Method of Identifying Patients Suitable for High-Dose Cyclophosphamide Treatment (JHU ref. C05071) Aldehyde dehydrogenases (ALDHs) are intracellular enzymes responsible for oxidizing aldehydes. A number ... More...   The Consensus Coding Sequences of Breast and Colorectal Cancers (JHU ref. C05042) Human cancer is a disease caused by an accumulation of mutations in genes involved in cell cycle regulation. ... More...   Targeting of Stat-3 Signaling in the Hematopoietic System Evokes Multicomponent Therapeutic Antitumor Immunity (JHU ref. C04665) The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends ... More...   Neovascular and (alpha)(nu)(beta)3/5 Retargeted Adenovirus Delivering Interleukin-12 (JHU ref. C04534) This invention employs an engineered retargeted adenoviral vector to locally deliver genes with immunologically ... More...   Mutational analysis of the tyrosine phosphatome in colorectal cancers (JHU ref. C04435) JHU researchers have performed a comprehensive mutational analysis of the protein tyrosine phosphatases ... More...   Antibody to Human DNA Methyltransferase 1 (JHU ref. C04328) We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human ... More...   Inhibitors of Beta Lactamase (JHU ref. C04224) The invention provides novel non-.beta.-lactam inhibitors of .beta.-lactamases. In particular, the invention ... More...   BRAF Mutation Occurs in a Majority of Papillary Thyroid Carcinoma (JHU ref. C04213) The BRAF gene was recently found to be activated by mutation in human cancers, predominantly in malignant ... More...   Novel Tyrosine Kinases Implicated in Colorectal Cancers (JHU ref. C04145) Tyrosine kinases (TK) are the regulators of signaling pathways that control cellular functions such ... More...   In Vitro and In Vivo Induction of Potent Bystander Anti-Tumor Effects Through Inhibition of Stat3 Signaling (JHU ref. C03965) The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal ... More...   Method for Generating Uniquely Immunogenic Autoantigen Fragments as Tools to Prevent and Treat Autoimmunity, and Initiate Specific Anti-Tumor Immune Responses (JHU ref. C03362) The present invention provides a method of producing autoantigens, compositions comprising autoantigenic ... More...   A Photoreceptor Cell-Specific ATP Binding Transporter Gene (ABCR) is Mutated in Recessive Stargardt Macular Dystrophy (JHU ref. C03195) Vitelliform macular dystrophy (VMD/Best disease) is an early-onset autosomal dominant disorder in which ... More...   4.0 Demethyl Perclomedine (JHU ref. C03027) Substantially pure 3,5-dichloro-2-nethoxy-4-hydroxy-6-(trichloromethyl)pyridine or 4-demethylpenclomedine ... More...   Antimalarial and Antitumor Activities of Artemisinin-Derived Trioxane Dimers with High Potency, Selectivity, and Stability (JHU ref. C01754) In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale ... More...   Inhibitors of Plasmepsin II, an Anti-Malarial target (JHU ref. C01643) Compounds and methods for the inhibition of anti-malarial target aspartyl protease plasmepsins (e.g. ... More...   Method for High Throughput Thermodynamic Screening of Ligands (JHU ref. C01507) The optimization of lead compounds as viable drug candidates involves the optimization of their binding ... More...   Trioxane Dimer Compounds Having Antiproliferative and Antitumor Activities (JHU ref. C01306) Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities. More...   Chemoprotective Isothiocyanates (JHU ref. C01218) Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in ... More...   High Affinity Inhibitors of Coronavirus Proteases 3CLpro (JHU ref. 10144) Coronaviruses are responsible for many respiratory and gastrointestinal infectious processes in humans. ... More...   A New Molecular Target for Cancer Therapy  (JHU ref. C10116) Many human cancers are refractory to conventional therapeutic approaches. Therefore, identification ... More...   Antipsychotic Drugs that do not elicit Weight Gain by Screening for Influences on Hypothalamic AMP-Kinase and Histamine H1 Receptors (JHU ref. 5045) Atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their ... More...   Site-specific Modification of the Human Genome Using Custom-designed ZFNs (JHU ref. 4775) Scientists at JHU have designed sets of Zinc Finger Nucleases (ZFN) to target mouse genes, namely the ... More...   Use of dithiocarbamates for the treatment of tuberculosis (JHU ref. 10091) Tuberculosis (TB) remains a major threat to global health despite the availability of anti tuberculosis ... More...   Use of Quinolinol and related compounds for the treatment of tuberculosis  (JHU ref. 10092) Tuberculosis (TB) remains a major threat to global health despite the availability of anti tuberculosis ... More...   Formation of Functional Motor units and Recovery from Paralysis Using Embryonic Stem Cell Transplantation. (JHU ref. 4995) The technology describes the potential of embryonic stem cell-derived motor neurons to functionally ... More...   An Assay to Identify Novel Targets and Personalize Combination Anticancer Therapy  (JHU ref. 5174) Scientists at JHU have developed a pharmacodiagnostic assay to identify relevant targets and direct ... More...   Novel Drug Development For Cancer (JHU ref. 5184) Benzoylphenylurea (BPU) derivatives have been shown to have potent anineoplastic activity in vitro and ... More...   Identification of a specific ligand for Siglec-8 (JHU ref. 4430) JHU scientists have created a unique, carbohydrate-based chemical structure that binds to the cell surface ... More...   Platelet Endothelial Cell Adhesion Molecule-l Gene Polymorphism and its soluble level are associated with severe coronary stenosis in Chinese and Asian Indians  (JHU ref. 4600) Many established risk factors in atherosclerosis and Coronary Artery Disease (CAD) have been defined ... More...   Toxic Role of Heme Oxygenase in Hemorrhage  (JHU ref. 5149) JHU scientists have investigated the contribution of inducible HO-1 to early brain injury produced by ... More...   MicroRNA-based Diagnostic Testing and Therapies for Inflammatory Bowel Disease (JHU ref. 5191) Ulcerative colitis (UC) and Crohn's disease (CD) are the two most common chronic inflammatory bowel ... More...   Proteins involved in pulmonary, cardiac and inflammatory disorders (JHU ref. 4858) Scientists at JHU have discovered a novel protein and its related family members and receptors. The ... More...   Novel protein increases muscle mass (JHU ref. 5182) Muscle mass is normally regulated by the activities of members of the transforming growth factor-ß (TGF-ß) ... More...   Identification of mesothelin epitopes that are the targets of vaccine induced immune responses. (JHU ref. 5175) This invention describes the discovery of 5 new mesothelin derived epitopes that are recognized by immunized ... More...   Novel Anticancer Drug Leads (JHU ref. 10040) A novel target for cancer therapy has been discovered by JHU scientists. The drug azalanstat appears ... More...   Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic Treatment  (JHU ref. 10039) Targeted tumor therapy is commonly based on the use of antibodies directed against a specific molecule, ... More...   CanScript for Gene Therapy: A DNA enhancer element conveying cancer-specific expression to 30% of human malignancies (JHU ref. 5183) One of the major requirements for effective cancer gene therapies are DNA sequences that, when inserted ... More...   Myc-repressed microRNAs as novel anti-cancer therapeutic agents (JHU ref. 5164) MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency ... More...   A Novel Agent to Reduce the Requirement of Inhalational Anesthetics in Clinical Anesthesia. (JHU ref. 5160) Postsynaptic density protein-95 (PSD-95), a scaffolding protein, has been identified to attach NMDA ... More...   A Novel Agent to Reduce the Requirement of Analgesics in Clinical Pain Management. (JHU ref. 5159) N-methyl-d-aspartate (NMDA) receptor activation has been demonstrated to play an important role in the ... More...   Formulation of Toll-like Receptor Ligand With Whole Cell Tumor Vaccine to Enhance Anti-tumor Responses (JHU ref. 5152) Established reports in literature have shown that the innate immune system can modulate immune responses ... More...   MicroRNA Expression and Control of Stem Cell Pluripotency, Differentiation and Cellular Processes (JHU ref. 5118) MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind to the 3' untranslated region of mRNAs ... More...   Near infrared fluorescent 6-O-glucosamine compounds with targeting specificity to lysosomes in tumors  (JHU ref. 5019) Optical imaging is a non-invasive, diagnostic imaging technology which can be used to inexpensively ... More...   Trioxane Dimers Having Surprisingly High Anticancer Activities and Surprisingly Long-lasting Antimalarial Activities (JHU ref. 4882) Artemisinin (1), a monomeric 1, 2, 4 trioxane, is usually administered for the treatment of multi-drug ... More...   Methods for Inducing Immune Tolerance By Inhibiting the Fas Pathway. (JHU ref. 5129) Fas ligand ("FasL") is a protein with an activity to induce apoptosis of a Fas antigen ("Fas")-expressing ... More...   A novel antibody to platelet endothelial cell adhesion molecule-l (JHU ref. 5134) PECAM-l (CD 31), a member of the IG superfamily, is expressed strongly at endothelial cell junctions, ... More...   Biofunctional Fibers (JHU ref. C05138) The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization ... More...   A Persistence Switch Involved in Persister Formation and Tolerance to Multiple Antibiotics and Stresses, as a Drug Target for Persister Bacteria (JHU ref. 5126) Persister bacteria are metabolically quiescent cells that neither grow nor die in the presence of antibiotics. ... More...   Antithrombotic Agent (JHU ref. 5127) Scientists at JHU have discovered a new pathway that modulates platelet activation through a receptor ... More...   Fumarranol, A Rearranged Fumagillin Analog That Inhibits Angiogenesis in vivo (JHU ref. 5034) Angiogenesis, the formation of new blood vessels, is involved in the pathogenesis of a number of common ... More...   Controlled Microencapsulation of Mammalian Cells (JHU ref. C05121) The present invention is directed to an automated device and method to prepare polyelectrolyte microcapsules ... More...   Generation of Xenografts on Mice to Tailor Anticancer Therapy from Fine Needle Aspiration Biopsies (JHU ref. 5107) Xenografts can be made from resected tumors of pancreatic cancer patients in order to generate tumor ... More...   Use of EP3 Receptor Ligands to Reduce Damage from Stroke and Other Neurological Disorders  (JHU ref. 5095) Cyclooxygenase (COX)-2 inhibitors are well known for their use as anti-inflammatory agents and have ... More...   An approach to guide the individualized development of new anti-cancer agents (JHU ref. 5096) The development of new oncology drugs has not resulted in a meaningful improvement in survival of cancer ... More...   Use of High-dose Oxazaphosphorine Drugs in Combination with Monoclonal Antibodies for Treating Immune Disorders (JHU ref. 5098) Autoimmune diseases afflict more than 8 million people in the U.S alone. Autoimmunity usually occurs ... More...   Specific T Lymphocyte Population Essential for Acute Lung Injury Recovery  (JHU ref. c05092) Acute lung injury and acute respiratory distress syndrome are sources of substantial morbidity/ mortality ... More...   Use of Novel Derivatives of Artemisinin to Inhibit Toxoplasma gondii  (JHU ref. 5086) Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a medically important infection and is ... More...   Inhibition of Transplantation Rejection by Suppressing HVEM (JHU ref. 5085) Decoy lymphotoxin beta receptor (LTßR) has potent immune inhibitory activities, and thus represents ... More...   Use of High Dose Cyclophosphamide in Combination with Anti-Idiotypic Vaccines in Anti-cancer Therapy (JHU ref. 5073) Recently, immunotherapy based techniques have been developed for the treatment of various cancers. ... More...   Use of High Dose Cyclophosphamide in Combination with Immune Therapeutics in Anti-Cancer Therapy (JHU ref. 5072) Cyclophosphamide and especially high-dose cyclophosphamide has been used for the treatment of certain ... More...   Rapid predictive assay for malignancies treated with polo-like kinase-1 (PLK1) inhibitors and cell cycle modulators (JHU ref. 5065) Scientists at JHU have developed a pharmacodiagnostic assay for patients treated with targeted therapies ... More...   Protective effect of carbon monoxide (CO) in stroke (JHU ref. 5062) Carbon monoxide (CO) has been shown to mediate both beneficial and deleterious processes in the central ... More...   Multiple Roles for HOXB7 in Breast Cancer (JHU ref. 5063) Epithelial-mesenchymal transition (EMT) is increasingly recognized as a mechanism whereby cells in primary ... More...   Small Molecules targeting 5-meCpG Binding Domain Proteins for Cancer Prevention and Treatment (JHU ref. 5053) JHU scientists have discovered new small molecules inhibitors of the transcriptional repression pathway ... More...   Inhibition of Vif-Cul5 interaction as target for potential HIV drug development (JHU ref. 5051) The Vif – A3G axis is one of the most promising new drug targets in HIV research. Previous studies ... More...   Melanoma Metastasis-Associated Genes as Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma (JHU ref. 5041) The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States ... More...   The Consensus Coding Sequences of Breast and Colorectal Cancers (JHU ref. 5042) Human cancer is a disease caused by an accumulation of mutations in genes involved in cell cycle regulation. ... More...   Monoclonal antibodies (mAB) specifically against mouse and human LIGHT and B7-H4 molecules (JHU ref. 5037) Scientists at JHU have made monoclonal antibodies against mouse and human LIGHT and B7-H4 molecules. More...   MicroRNAs as targets for anti-angiogenesis therapies (JHU ref. 5032) MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency ... More...   Drugs Targeting Cancer Stem Cells (JHU ref. 5028) The study of cancer stem cells is important for the development of new cancer treatments. Existing ... More...   Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant  (JHU ref. 5018) Human telomerase reverse transcriptase (hTERT) is activated in thyroid cancer. Despite this, its usefulness ... More...   Multitypic Recombinant Adenovirus Vaccines against HPV and Malaria (JHU ref. C05017) JHU scientists have developed vaccines against human papillomavirus (HPV) infection and malaria, consisting ... More...   Aspirin and Ibuprofen Improve Pyrazinamide Treatment of Tuberculosis (JHU ref. 5088) The non-steroidal anti-inflammatory drugs aspirin and ibuprofen are widely used in the treatment and ... More...   Liposomase for the tumor-specific delivery of chemotherapeutic drugs (JHU ref. 5007) The challenge in developing effective cancer treatments is in achieving specificity so that only cancer ... More...   EmboGel/EmboClear therapeutic solution – a dissolvable radio-opaque alginate-based biomaterial for endovasclar delivery and controlled therapeutic agent release. (JHU ref. 5004) EmboGel is a novel biocompatible, radio-opaque polymer that combines an FDA approved alginate with one ... More...   A novel class of anti-thrombotic agents that specifically inhibit inflammation-related vascular occlusion. (JHU ref. 5005) Inflammation is known to be an integral part of the vascular occlusive events that occur during heart ... More...   Epigallocatechin-3-Gallate (EGCG) Enhances CD8+ T Cell Mediated Anti-Tumor Immunity Induced by DNA Vaccination  (JHU ref. 5000) Immunotherapy and chemotherapy are generally effective against small tumors in animal models of cancer, ... More...   Use of Curcumin for Prevention and Treatment of Gastrointestinal Neoplasia. (JHU ref. 4996) Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by the development ... More...   Tumor Repressor Genes in the Prevention of Cancer (JHU ref. 4992) Some epidemiological studies suggest that many solid tumor types occur less often than predicted in ... More...   Enhanced Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma (JHU ref. 4977) Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key ... More...   Structural and Biochemical Characterization of Nampt for Use in Drug Design to Treat Diabetes, Neurodegeneration and Cancer  (JHU ref. C04976) Nicotinamide phosphoribosyltransferase (Nampt), which synthesizes nicotinamide mononucleotide (NMN) ... More...   Inhibitors of Human Methionine Aminopeptidase 1 as Novel Anti-Cancer Drug Leads (JHU ref. 5106) JHU researchers have unraveled an important function of human type 1 aminopeptidase (hMetAP1) in the ... More...   The novel effects of NAD-related compounds (nicotinamide, nicotinamide mononucleotide, and NAD) on blood glucose levels.  (JHU ref. 4965) Scientists at JHU have discovered of a novel blood-circulating form of Nampt. This novel isoform a slightly ... More...   A Screening Assay for the Identification of Functional Defects in the Proximal Fanconi Anemia Pathway (JHU ref. 4962) Inactivation of Fanconi Anemia (FA) genes occurs in a variety of tumors among the general population ... More...   A Method of Screening a Compound which Induces CPT-1C Expression or Functionally Activates CPT-1C for the Treatment of Obesity and/or Diabetes.  (JHU ref. 4959) Fatty acid synthesis in the central nervous system has been implicated in the control of food intake ... More...   Phase 2 Inducers and Related Signaling Pathways Protect Cartilage Against Inflammation/Infection, Apoptosis and Stress (JHU ref. 4957) The molecular pathogenesis of arthritis associated with increased chondrocyte apoptosis is earmarked ... More...   Discovery of a novel oncogene involved in breast cancer (JHU ref. 4936) TGF-beta signal transduction is a primary tumor suppression pathway in breast cancer. Many breast cancer ... More...   Augmentation of Endocardial Thromboresistance (JHU ref. 4927) A critical function of the endocardium is to maintain local thromboresistance by providing an anticoagulant ... More...   Identification of E. coli Determinants Contributing to Bacteremia That Form the Foundation for Prevention of E. coli Bacteremia and Sepsis (JHU ref. 4942) E. coli is the most common gram-negative organism causing nosocomial bacteremia and bacteremia in VA ... More...   HOXB7 as a Potential Prognostic Marker and Therapeutic Target in Cancer (JHU ref. 4922) Scientists at The Johns Hopkins University have determined that HOXB7, a member of homeobox superfamily ... More...   Mycobacterial Catalase-peroxidase in the Diagnosis and Treatment of Sarcoidosis (JHU ref. 4915) Sarcoidosis is an organ-wide inflammatory disease of unknown etiology that is characterized by the presence ... More...   Neuroprotective Actions of Polyphenols, Flavonoid Derivatives and Their Respective Extracts (JHU ref. 4913) Polyphenols, such as resveratrol, have been linked to many health benefits. This widespread belief ... More...   Novel Difluoromethyl Analogs of Calcitriol (JHU ref. 4909) The natural hormone calcitriol, the most active metabolite of vitamin D, exhibits significant chemotherapeutic ... More...   Compounds with effects on potassium channels (JHU ref. 4902) KCNQ channels play a role in cardiac and neuronal membrane excitability. Scientists at JHU have identified ... More...   Inducing and inhibiting T cell tolerance with A2a receptor agonists and antagonists (JHU ref. 4897) T cells play a critical role in fighting disease and infection. However, when T cells recognize and ... More...   Identification of the Most Common Gene for Bardet-Biedl Syndrome (JHU ref. 4887) Bardet-Biedl syndrome (BBS) is characterized by multiple clinical phenotypes including retinal dystrophy, ... More...   Novel Compounds that Target Estrogen Receptor (ER) Positive Tamoxifen-resistant Breast Cancers (JHU ref. 4885) The drug tamoxifen is widely used to treat estrogen receptor (ER) positive breast cancer and to prevent ... More...   Antibody Based Anti-HIV-1 Microbicide Targeting a Host Protein (JHU ref. 4854) Development of microbicides to prevent HIV-1 transmission to women plays a valuable role in stemming ... More...   Novel methods for genetic calcium channel blockade (JHU ref. 4863) The development of left ventricular hypertrophy (LVH), irrespective of etiology, confers an incremental ... More...   TGFß Antagonists, including AT1 Receptor Blockers, Rescue the Multisystem Pathogenesis of Marfan Syndrome (JHU ref. 4861) This invention is based on the discovery that excessive activity of an important signaling protein, ... More...   Peptide Substrates for Fibroblast Activation Protein (FAP) that can be used to Generate FAP-activated Prodrugs and Protoxins (JHU ref. 4855) Fibroblast activation protein alpha (FAP-alpha) is a membrane bound serine protease that is only produced ... More...   Prostate Specific Membrane (PSMA)-binding Peptides Useful for Targeted Therapy for Cancer (JHU ref. 4856) Prostate-Specific Membrane Antigen (PSMA) is a glutamate carboxypeptidase II that is expressed by normal ... More...   Transcatheter Arterial Embolization of Selective Gastric Arteries to Suppress Gastric Hormones that Contribute to Appetite Formation and Obesity. (JHU ref. 4838) The prevalence of overweight and obesity is increasing worldwide and developed countries have high obesity ... More...   Tetrahyrdobiopterin for treatment of cardiac failure and remodeling (JHU ref. 4836) Tetrahyrdobiopterin (BH4) is an obligate cofactor for the aromatic amino acid hydroxylases (tyrosine, ... More...   Identification of Cancer Drug Targets as Common Nodes in Genetic Interaction Maps (JHU ref. 4826) A major goal in biology is to identify all genes whose function contributes to the maintenance of genome ... More...   Valosin Containing Protein (VCP)/p97 Gene Inhibition Rescues Cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation (JHU ref. 4824) Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant ... More...   Rescue of the Cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation using Proteasome Inhibitors. (JHU ref. 4825) Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant ... More...   New uses for old drugs: Identification of Hedgehog pathway antagonists previously tested in humans (JHU ref. 4820) Hedgehog (Hh) pathway activity is responsible for the growth of lethal cancers such as small cell lung ... More...   Development of Novel Approaches to Combinatorial Antifungal Drug Therapy (JHU ref. 4532) This invention relates to a method of treating fungal infections. Fungal infections can be life-threatening ... More...   Identification of PSCA as an Immune Relevant Target of Antitumor Immune Responses. (JHU ref. 4605) Prostate Stem Cell Antigen (PSCA) was previously identified as a biomarker for pancreatic and prostate ... More...   Selectively Targeted Histone Deacetylase Inhibitors (JHU ref. 4643) Inhibitors of histone deacetylases (HDAC) are regarded as an important approach to cancer chemotherapy, ... More...   Arginase, A Target Enzyme for the Treatment of Myocardial Dysfunction in Aging and Heart Failure (JHU ref. 4729) This invention comprises a novel method to treat heart failure and age-related myocardial dysfunction ... More...   Novel Imaging Agent to Detect Multidrug Resistance in Tumors Using Multimodality Imaging (JHU ref. 4776) Multidrug resistance (MDR) can develop during chemotherapy to desensitize tumors to a variety of structurally ... More...   Molecular Targets for the Anti-cancer Natural Product Pateamine A and its novel synthetic derivatives (JHU ref. 4774) The natural marine product Pateamine A (PatA) is a potent anti-tumor and pro-apoptotic agent. Until ... More...   Nrf2 as a Target for Intervening Pulmonary and Systemic Inflammation (JHU ref. 4768) Sustained inflammation is critical in the development of several pathophysiological diseases such as ... More...   Novel Diagnostic & Prognostic Markers & Therapeutic Targets for melanoma (JHU ref. 4578) The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States ... More...   Interference of the mir-17 miRNA Cluster as a Novel Cancer Therapeutic Strategy (JHU ref. 4742) The MYC cancer gene increases the expression of a cluster of microRNAs that are implicated in the development ... More...   Neuroprotective Actions of EP Receptor ligands to Reduce Damage from Stroke and Other Neurological Disorders  (JHU ref. 4732) Prostaglandin E2 is the primary product of arachidonic metabolism and is synthesized via the prostaglandin ... More...   PGE2 EP2 Receptor Antagonists in Alzheimer's Disease and Neuroinflammation (JHU ref. 4730) A number of neurological diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral ... More...   Sequence Motifs that Direct Nuclear Import of Small RNAs (JHU ref. 4987) Small RNA species, such as small-interfering RNAs (siRNAs) and microRNAs (miRNAs), have important roles ... More...   Mutational Analysis of the Serine-Threonine Kinome in Colorectal Cancers (JHU ref. 4724) The invention describes novel mutations in serine-threonine kinase genes within the Phosphatidylinositol-3-OH ... More...   Hypoxia-induced Mitogenic Factor (HIMF) As a Treatment for Acute Lung Injury (JHU ref. 4711) Lipopolysaccharide (LPS) is a component of the outer membrane of gram-negative bacteria that induces ... More...   Inhibition of Ischemia-induced Arrythmias by Blocking Mitochondrial Inner Membrane Ion Channels (JHU ref. 4696) Coronary heart disease (CHD) is the number one killer in the United States, each year claiming more ... More...   Formation of Functional Motor units and Recovery from Paralysis Using Embryonic Stem Cell Transplantation (JHU ref. 4687) A major problem in in vitro fertilization (IVF) clinics is that many human embryos do not survive or ... More...   Method for the direct extraction of isothiocyanates into the seed oil from glucosinolate-containing plant seeds (JHU ref. 4570) JHU researchers have developed a methodology for simple, reliable, stable, and inexpensive incorporation ... More...   Growth of mesenchymal stem cells under non adherent conditions for clinical applications (JHU ref. 4683) The use of bone marrow derived mesenchymal stem cells (MSC) has been proposed for a number of regenerative ... More...   Activation of the Ciliary Neurotrophic Factor Receptor Reverses Cardiac Hypertroph (JHU ref. 4779) The increasing incidence of obesity in the US population brings with it a concomitant increase in the ... More...   A Reactive Oxygen Generating Enzyme Inhibitor That Reverses Mechanoenergetic Uncoupling in the Failing Heart (JHU ref. 4674) In the US, CHF is the number one cause of hospitalization in people over age 65, and it affected approximately ... More...   A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics (JHU ref. 4582) JHU researchers have discovered a novel peptide prototype, target and screening assay for neuronal calcium ... More...   Single cell analysis of HIV replication capacity and drug resistance (JHU ref. 4395) This invention provides an assay to simultaneously analyze residual susceptibility and reduced replication ... More...   Development of a DNA vaccine targeting HPV-16 oncoprotein E6 (JHU ref. 4450) Human papillomavirus (HPV), particularly type-16, is present in over 99% of cervical cancers. The HPV ... More...   Cancer Immunotherapy Using a DNA Vaccine Encoding a Single-Chain Trimer of MHC class I Linked to an HPV-16 E6 Immunodominant CTL Epitope (JHU ref. 4451) The potency of DNA vaccines may be affected by the efficiency of intracellular processing and MHC class ... More...   A Novel PGC-1alpha/SIRT1 Deacetylase Interaction (JHU ref. 4471) Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels ... More...   Therapeutic Target for Both Cancer and Ischemic Diseases  (JHU ref. 4536) This invention addresses two desired outcomes relating to cells exposed to ischemic or low oxygen tension ... More...   Medical Device for treatment of Ulnar Neuropathy (JHU ref. 4545) Ulnar nerve abnormalities are found in as many as 40% of adult Americans. Often due to excessive flexion ... More...   A method for high-efficiency clonal isolation and expansion of human embryonic stem cells (JHU ref. 4575) JHU researchers have developed a method and identified growth factors for high efficiency cloning, clonal ... More...   Drug Eluting Embolic Coils for Treatment of Vascular Aneurysms (JHU ref. 4576) Guglielmi Detachable Coils (GDCs) are commonly used for endovascular therapy of intracranial aneurysms. ... More...   PDE inhibitors in immunotherapy (JHU ref. 4580) Defects in the immune system of tumor-bearing hosts can dramatically preclude effective immune-therapy. ... More...   Facile Modification of Collagen Directed by Synthetic Peptides (JHU ref. 4571) Currently, there is significant biomedical interest in modifying natural collagen to improve its biochemical ... More...   Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants (JHU ref. 4630) Vaccines for diverse viruses will be most effective when they direct the recipient’s response to recognize ... More...   The Amino Acid Noose of the Attachment Protein of Respiratory Syncytial Virus (RSV) Inhibits the Effects of the Endotoxin and the Innate Immune Response (JHU ref. 4477) Both endotoxin and RSV protein F stimulate CD14/TLR4 receptor in monocyte/macrophages resulting in a ... More...   Selective Dorsal Rhizotomy of Pain Signaling Nerve Fibers (JHU ref. 4516) JHU researchers have invented a technique that allows selective blockade of the neuronal input of nociceptive ... More...   Transgenic Frog Lines to Study Retina Degeneration (JHU ref. 4517) A JHU researcher has developed lines of transgenic frogs in which transgenes induce photoreceptor degeneration ... More...   Neovascular and Retargeted Adenoviral Delivery of Therapeutic Genes Sequences  (JHU ref. 4534) This invention employs an engineered retargeted adenoviral vector to locally deliver genes with immunologically ... More...   Neurotrophic Factor for Spinal Motor Neurins and Dorsal Root Ganglion (JHU ref. 4538) Chronic neurodegenerative illnesses that affect the peripheral nervous system (PNS), such as amyotrophic ... More...   A Novel Genetic Approach to inhibit or Eliminate the Tumorgenicity of Human Embryonic Stem Cells and/or their Derivatives After Transplantation. (JHU ref. 4622) Pluripotent embryonic stem cells have enormous potential for providing an unlimited supply of multipotent ... More...   Modification of Professional Antigen-Presenting Cells with Small Interfering RNA (siRNA) Targeting BAK and/or BAX Can Enhance DNA Vaccine Potency  (JHU ref. 4464)        It is now clear that dendritic cells (DCs) are the most potent professional antigen presenting ... More...   Test for Colon Cancer Adenoma Formation Risk and Possibly Risk of Other Tumor Type Formation (JHU ref. 4482) This invention provides a strategy for identifying patients at risk of colorectal cancer, and likely ... More...   Structural Prediction of Allosterism  (JHU ref. 1539) During the course of biological function, proteins interact with other proteins, ligands, substrates, ... More...   Strategies for Designing Drugs that Target the Sir2 Family of Enzymes (JHU ref. 4598) Sir2 enzymes comprise a unique class of NAD+ -dependant protein deacetylases that are involved in a ... More...   Widespread Requirement for Ligand-stimulated Hedgehog Pathway Activity in Growth of Digestive Tract Tumors (JHU ref. 4283) This work demonstrates that hedgehog (Hh) pathway activity plays a critical role in the growth of cancers ... More...   Novel Drug Development for Breast Cancer II (JHU ref. 4391) A series of boronic-chalcone derivatives were synthesized and tested for anti-tumor activity against ... More...   Myocyte Enhancer Factor 2 (MEF2) Mediates Calcium-Dependent Transcription of the Interleukin-2 Gene in T Lymphocytes (JHU ref. 4386) MEF2 is a transcription factor that is known to play a role in muscle differentiation and thymocyte ... More...   Mutations of the PIK3CA Gene in Human Cancers  (JHU ref. 4407) Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important ... More...   Hypomorphic Mouse Mutant of PASG, an SNF2L Factor, That Leads to Growth Retardation and Premature Aging (JHU ref. 4428) Researchers at JHU have shown that PASG (Proliferation Associated SNF2-Like gene, also termed lsh or ... More...   Identification of a Binding Partner for the Endothelial Cell Surface Proteins (JHU ref. 4513) Targeting the endothelial cells that line tumor blood vessels is a promising new strategy for the treatment ... More...   Systemic Delivery of Compounds through Noninvasive Bladder Administration  (JHU ref. 3767) The present invention provides methods for the delivery of a therapeutic agent to lymph nodes or other ... More...   Hedgehog Pathway Antagonists (JHU ref. JHU Ref. 4341) The Hedgehog pathway is known for its important role in inductive interactions that regulate growth ... More...   Wnt Pathway Antagonists   (JHU ref. JHU Ref. 4342) The Wnt signaling pathway is known for its important role in inductive interactions that regulate cellular ... More...   Prevention and Treatment of Erectile Dysfunction (JHU ref. JHU Ref. 4446) JHU researchers have demonstrated an FDA approved drug commonly used to treat other diseases recovers ... More...   New Inhibitor of HIV-1 Replication, Ubiquitin Like Protein ISG15  (JHU ref. 4478) The AIDS epidemics are still not limited, especially in the developing countries. The antiviral therapy ... More...   Imaging Bacteria with Light-emitting Substrates of Thymidine Kinase  (JHU ref. 4488) JHU researchers describe a simple and specific method for imaging bacteria using light-emitting substrates ... More...   Cloning and Isolation of the Large Ribosomal Subunit Proteins from E. coli for the in vitro reconstitution of functional 50S Subunits (JHU ref. 4466) For the first time, JHU researchers have cloned, expressed and purified each of 34 individual large ... More...   Use of Amniotic Fluid (AF) in Ocular Disease (JHU ref. 4512) Human amniotic membrane (HAM) has been used successfully in recent years to treat various ocular ailments ... More...   Control of Proliferation and Apoptosis in Cancer Cells (JHU ref. 4447) pp32 (ANP32A) is a protein expressed in stem-like normal cellular compartments and in human cancers, ... More...   A method of drug delivery for control of Schistosomiasis and other cercarial-derived trematode infections (JHU ref. 4448) Schistosomes are human and animal parasites that cause serious disease by living in the blood vessels ... More...   Method for Targeting Motor Neurons  (JHU ref. JHU Ref. 4439) Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy are disorders of motor neurons for which there ... More...   Suppression of HIV Replication and Prevention/Treatment of HIV-Associated Dementia (JHU ref. 4222) This invention describes the addition of a tetracycline derviative to existing combinations of antiretroviral ... More...   Vascular Barrier Protective Properties of Bioactive Components of Oxidized Phospholipids Released During Acute Injury Conditions  (JHU ref. JHU Ref. 4366) Following an acute phase of inflammation or injury, restoration of the endothelial barrier is important ... More...   Inhibitors of N-ethylmaleimide Sensitive Factor  (JHU ref. 4180) JHU researchers have discovered that a previously described protein N-ethylmaleimide Sensitive Factor ... More...   OS-9 Interacts with Hypoxia-inducible Factor 1(alpha) and Prolyl Hydroxylases to Negatively Regulate HIF-1 Activity. (JHU ref. 4476) Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan ... More...   T Cell Modulation to Prevent/Treat Cisplatin Nephrotoxicity. (JHU ref. 4465) Cisplatin is an organic metal widely used for genitourinary, head and neck and lung cancers. Kidney ... More...   Prevention and/or Treatment of Neurodegenerative Diseases by Elevation of Glutathione and Phase Detoxification Enzymes (JHU ref. 3728) A wealth of data has unambiguously showed that cellular glutathione (GSH) protects neurons against degeneration ... More...   Novel Approach for Tackling Cancer Chemoresistance (JHU ref. 4440) The current cancer treatment regime of surgery, radiotherapy and chemotherapy can fail due to multidrug ... More...   A Novel Human T-cell Lymphotropic Virus, Designated HTLV-4 (JHU ref. 4433) This invention describes the identification and molecular characterization of a novel human T-cell lymphotropic ... More...   Vitamin D3 Analogues (JHU ref. JHU Ref. 1153) The present invention is based on the unexpected finding that the A-ring portion of vitamin D.sub.3 ... More...   1, 2, 4 - Trioxanes Having Antimalarial Activity (JHU ref. JHU Ref. 1158) Because of the widespread incidence of malaria in certain parts of the world and because of the increasing ... More...   Formation of Oligonucleotide Triplexes with Selectively Modified Cytosines  (JHU ref. JHU Ref. 1179) The present invention is based on the finding that it is possible to use the bisulfite-catalyzed transamination ... More...   Antiproliferative Vitamin D3 Hybrids (JHU ref. JHU Ref. 1276) The present invention is based on the unexpected finding that certain modifications to the A-ring portion ... More...   A Defective Response to Hedgehog Signaling In Disorders of Cholesterol Biosynthesis (JHU ref. JHU Ref. 4215) This invention provides a method to stimulate stem or progenitor cells with a signaling molecule in ... More...   Potent, Simplified Derivatives of the Immunosuppressive Agent, Pateamine A (PatA). (JHU ref. 4420) Pateamine A (PatA), a metabolite from the marine sponge Mycale, is a potent inhibitor of the intracellular ... More...   Adeno-Associated Viral Gene Therapy For Cystic Fibrosis. (JHU ref. 4361) Cystic fibrosis (CF) is caused by a defect in the cystic fibrosis transmembrane conductance regulator ... More...   Neuroprotective effects of Activation of Prostaglandin (JHU ref. 4339) Neurological diseases that involve neurodegeneration or acute neurological syndrome are characterized ... More...   Hedgehog Pathway Antagonism for the Prevention and Treatment of Metastatic Prostate Cancer (JHU ref. 4334) Prostate cancer is the most commonly diagnosed malignancy in men in the United States. Although most ... More...   Treatment of Persistent Bacterial Infections with Energy Inhibitors  (JHU ref. 4332) Persistent and non-growing pathogenic bacteria that are not killed by conventional antibiotics present ... More...   Use of NADPH-dependent alkenal/one oxidoreductase in the Bioactivation of Irofulven and Related Compounds that Preferentially Kill Cancer Cells (JHU ref. 4330) Irofulven (6-hydroxymethylacylfulvene, HMAF) is a novel anticancer chemotherapeutic that is under extensive ... More...   Phosphodiesterase 5 Inhibition for Treatment of Cardiac Hypertrophy  (JHU ref. 4322) Phosphodiesterase (PDE) enzymes are a family of proteins that degrade cyclic nucleotides; thus, playing ... More...   Polymerized Myoglobins as a blood Substitute (JHU ref. 4304) JHU researchers, in collaboration with other researchers, are developing artificial oxygen carriers ... More...   A p105-based NF-(kappa)B Super repressor (JHU ref. 4290) Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, ... More...   Pigment Epithelium-derived Factor as a Therapeutic Agent for Vascular Leakage, and a Peptide or Small Molecule Surrogate as Therapeutic Agent for Vascular Leakage and Neovascularization (JHU ref. 4288) Increased vascular leakage is a common feature of a number of disease states, including but not limited ... More...   Modulation of Insulin Secretion by Targeting a Novel Pancreatic Hyperpolarization-activated Current Via Pharmacological Intervention and/or Somatic Gene Transfer  (JHU ref. 4276) An estimated 16 million people in the US alone suffer from diabetes, a disorder of glucose metabolism ... More...   Method of Gene Transfer to the Cardiac Atria (JHU ref. 4263) Successful myocardial gene transfer remains an elusive target. Methods used to date include direct injection, ... More...   Manipulation of Regulatory T Cells using LAG-3 Antibodies, Genes, Agonists and Antagonists (JHU ref. 4255) Regulatory T cells (Treg) limit autoimmunity but also attenuate the potency of antitumor immunity. They ... More...   Isogenic Cell Lines with or without Intact BAX Genes (JHU ref. 4218) To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells ... More...   Use of hedgehog pathway inhibitors in small cell lung cancer (JHU ref. 4205) We have shown that small cell lung cancer (SCLC), a highly aggressive and frequently lethal tumor, uses ... More...   Method for producing diverse libraries of encoded polymers (JHU ref. 4204) With our reagents, libraries of drug-like molecules are rendered in a format where they can be subjected ... More...   Transcriptome of Human Hematopoietic Stem Cells  (JHU ref. 4191) The human CD34+/CD38-/Lin- cell subset comprises ~1-10% of the CD34+ cell population and includes few ... More...   Novel Tyrosine Kinases Implicated in Colorectal Cancers (JHU ref. 4145) Tyrosine kinases (TK) are the regulators of signaling pathways that control cellular functions such ... More...   Discovery of Novel Targets for Aberrant Methylation in Pancreatic Carcinoma Using Hight-throughput Microarrays (JHU ref. 4187) In order to identify potential targets for aberrant methylation in pancreatic cancer, we analyzed global ... More...   Glial Restricted Precursor Cells - Neuroprotectants and Modulators of Excitatory Neural Transmission (JHU ref. 4168) Glutamate is the primary excitatory amino acid neurotransmitter in the human brain. It is important ... More...   Apolipoprotein C-I promotes apoptosis in human arterial smooth muscle cells  (JHU ref. 4159) Apolipoprotein C-I, a small basic protein in human blood, induces apoptosis in cultured human arterial ... More...   Opportunity I: Inhibition of Hedgehog Signaling by Direct Binding of Cyclopamine to Smoothened Opportunity II: Efficient Drug Screening for Thousands of Protein Targets (JHU ref. 4147) Opportunity I: Dysregulation of the Sonic hedgehog-Patched-Gli pathway leads to several human diseases. ... More...   Use of a Tetracycline Derivative in Viral Diseases Indicators of the Central Nervous System   (JHU ref. 4146) Diseases associated with West Nile Virus (WNV) and other encephalitis viruses are increasingly common. ... More...   Using Nitroxyl Donors to Precondition the Heart Against Myocardial Infarction (JHU ref. 4118) The search for drugs to prevent or protect against myocardial infarction has been an important endeavor ... More...   Polyamine Analogues With Significant Antitumor and Antiparasitic Activity (JHU ref. 4089) Johns Hopkins researchers have synthesized a novel series of terminally alkylated polyamines that have ... More...   Novel Drug Development for Breast Cancer (JHU ref. 4085) A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against ... More...   Generation of HLA-Ig Based Artificial Antigen Presenting Cells (JHU ref. C04079) The goal of cell-mediated immunotherapy is to generate an effective anti-tumor or anti-infectious disease ... More...   Allelic Variation in Human Gene Expression (JHU ref. 4066) Understanding the genetic basis of human variation is one of the most important goals of modern biomedical ... More...   Expanding Human Embryonic Stem Cells Using human Adult (Marrow) Cells or Derived Molecules (JHU ref. 4064) All the existing human embryonic stem cells (hESCs) are derived and propagated on mouse embryonic fibroblasts ... More...   Hypoxia-induced Mitogenic Factor. (JHU ref. 4061) JHU researchers have discovered a novel cytokine named Hypoxia- Induced Mitogenic Factor (HIMF; also ... More...   Modulators of hedgehog Signaling (JHU ref. 4053) Members of the Hegdehog (Hh) family of secreted signaling proteins play critical roles in coordinating ... More...   A Chitosan-DNA Mucosal Vaccine For Respiratory Syncytial Virus Infection (JHU ref. 4047) A gene expression vaccine (GXV) comprising of a cocktail of pDNAs encoding nine immunogenic antigens ... More...   Nonstop Decay: A Novel mRNA Surveillance Mechanism that Degrades Readthrough Transcripts and other mRNAs Lacking Termination Codons (JHU ref. 4034) We have recently shown that transcripts lacking all termination codons (nonstop mRNAs) are specifically ... More...   Claudins as markers for early detection, diagnosis, prognosis and as targets of therapy for breast cancer  (JHU ref. 3995) We have recently identified Claudins 1, 3, 4, and 7 as differentially expressed in breast cancer relative ... More...   1. A Family of Novel Flavoenzymes, 151, that Binds Actin and Regulates Repulsive Axon Guidance Through Oxidation-Reduction Mechanisms and 2. A Role For Oxdidation of Actin In Limiting Axonal Outgrowth During Development and Following Neurological… (JHU ref. 3979) We have identified a class of proteins containing members which directly binds to the cytoplasmic domains ... More...   3-BROMOPYRUVIC ACID As a Potent Anticancer Agent Delivered Intraarterially (JHU ref. 3939) Liver cancer is one of the most common fatal cancers in the world and may reach epidemic levels in the ... More...   Targeting CD4+ Cells to Treat Ischemia Reperfusion Injury (JHU ref. 3931) There is currently no specific therapy for ischemic acute renal failure. We have recently identified ... More...   Beta-Secretase (BACE1) Polyclonal Antisera (JHU ref. 3929) To facilitate our understanding of the physiological role of BACE1 and its involvement in the generation ... More...   Cell Surface Tumor Endothelial Markers Are Conserved in Mice & Men (JHU ref. 3902) We identified four genes (TEM1, TEM5, TEM7, and TEM8) that displayed elevated expression during tumor ... More...   Use of Isogenic Human Cancer Cells for High-throughput Screening and Drug Discovery (JHU ref. 3894) A novel high-throughput drug screening strategy is described using isogenic human cancer cell lines ... More...   Use of Proaerolysin Toxins Modified to Contain Tissue Specific Protease Activation Sequences as Targeted Therapy For Cancer (JHU ref. 3887) Proaerolysin is a bacterial toxin that is normally activated by furin protease to produce the pore forming ... More...   Identification of P53-activating Compounds for Cancer Research and Therapy (JHU ref. 3857) An exciting,new invention from the laboratory of Dr. Scott Kern at The Johns Hopkins University School ... More...   Modulation of systemic Immune Responses by Transplantation of Hemotopoietic Stem Cells Transduced with Genes Encoding Antigens and Antigen Presenting Cell Regulatory Molecules (JHU ref. 3855) The initiation of T cell-dependent immune responses depends on presentation of antigens by bone marrow-derived ... More...   Fas Ligand-Expressing Hematopoietic Cells for Transplantation (JHU ref. 3827) Rejection of allografts is mediated by activated T cells that recognize alloantigen presented by dendritic ... More...   Digital Optical Imaging for Tracking Vascular Gene Expression and Early Diagnosis of Atherosclerosis (JHU ref. 3809) Atherosclerotic cardiovascular disease remains the leading cause of mortality in the United States. ... More...   A Novel Cytokine related structurally to IL-17 (JHU ref. 3801) A novel gene, designated ML-1, is identified, and shares sequence homology with the gene encoding IL-17. ... More...   FIH-1: Factor Inhibiting HIF-1 (JHU ref. 3784) Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates homeostatic responses ... More...   Enhancement of Vector Delivery for Virl Gene Transfer to Solid Organs (JHU ref. 3765) Prior work in the field of solid organ gene transfer has been limited by the efficiency of the delivery ... More...   Antiviral Compositions and Methods of Use (JHU ref. 1614) This invention is related to isolation of two highly potent, non-toxic inhibitors against human immunodeficiency ... More...   Tumor Suppressor Gene in Lung, Liver and Pancreatic Cancer (JHU ref. 3748) This invention relates to the discovery that TSLC1 (alias ST17) is down-regulated or inactivated in ... More...   Neuroprotection and Inhibition of Apoptosis by Mitrochondrial Potassium Channel Openers (JHU ref. 3742) Mitochondria can either enhance or suppress cell death. Cytochrome C release triggers apoptosis, but ... More...   Aberrantly Methylated Genes as Markers of Breast Malignancy in Ductal Fluids (JHU ref. 3729) The present invention is based on the finding that several genes are newly identified as being specifically ... More...   Gene Therapy for Cardiac Arrhythmias: In Vivo Alteration of Cardiac Electrophysiology by Somatic Gene Transfer (JHU ref. 3721) Potential therapies to control heart rate during atrial fibrillation include beta blocking or calcium ... More...   Application of Photochemotherapy for the Treatment of Cardiac Arrhythmias (JHU ref. 3717) Atrial fibrillation (very rapid random heartbeats) is the most common and debilitating electrical abnormality ... More...   An Inhibitor of Double Strand Break Repair (Non-Homologous End Joining) in Eukaryotic Cells (JHU ref. 1537) DNA damaging agents such as ionizing radiation and chemotherapeutics cause double-strand breaks in cellular ... More...   The Analgesic and Anesthetic Effects of Inhibiting the Interaction of the NMDA Receptor Subunits 2A/2B with Neuronal Nitric Oxide via PDZ Domain of PSD95/SAP90 (JHU ref. 3699) PSD-95/SAP90 is a molecular scaffold protein that, through interactions involving its PDZ domains, couples ... More...   Bisubstrate Analog Inhibitors for Protein Kinases (JHU ref. 3677) A new approach for the design of protein kinase inhibitors is disclosed. Using this approach a potent ... More...   Immunogenic Ovarian Cancer Genes (JHU ref. 3672) This invention is directed to the field of cancer diagnostics and therapeutics. In particular, this ... More...   “whmd”: Essential Cell Division Gene in Mycobacteria (JHU ref. 1506) The slow growth rate of mycobacteria contributes significantly to the pathogenes 'is and treatment of ... More...   Facilitation of the Expression in Eukaryotic Cells of Exogenous Genes by an Exogenous Compound (JHU ref. 3611) Scriptaid is a histone deacetylase inhibitor that provides a simple means of increasing the efficiency ... More...   The Analgesic and Anesthetic Roles of CGMP-Dependent Protein Kinase Ia Inhibitor (JHU ref. 3612) IA selective, potent and cell-permeable inhibitor of cGMP-dependent protein kinase Ia, without effects ... More...   Genetic Engineering of Autologous Vein Grafts with thrombomodulin-Expressing Vectors to Resist thrombosis, Neointimal Hyperplasia and Atherosclerosis (JHU ref. 3579) Autologous saphenous vein grafts (SVG) are the most widely used conduits for coronary artery bypass ... More...   Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin (JHU ref. 3569) The invention provides a family of proteins that by virtue of ankyrin domains, SH3 domains, PDZ domains, ... More...   Intraventricular Injection of Urokinase or other Thrombolytics (JHU ref. 3543) An experimental therapy that could accelerate the resolution of the blood clot and thus reduce the clot-related ... More...   Compositions and Methods for Prevention of HIV Transmission Across Mucosal Surfaces (JHU ref. 1443) Most newly acquired cases of HIV-1 infection result from sexual, primarily heterosexual, transmission. ... More...   Phenylalkenoic Acid-Mediated Corection of Aberant Protein Trafficking (JHU ref. 3517) This discovery encompasses the compound 4-phenyl-delta3-transbutenoic acid, which restores normal biosynthetic ... More...   Compositions and Methods for Modulating Serum Cholesterol (JHU ref. 3516) The sterol regulatory element binding protein-1(SREBP-1) serves in the gating mechanism in cholesterol ... More...   Water-Soluble Trioxanes as Potent and Safe Antimalarial Agents (JHU ref. 1320) Parasitic infections, particularly malaria, are a serious and widespread public health problem. New ... More...   C-10 Carbon-Substituted Artemisinin-Like Trioxane Compounds Having Antimalarial, Antiproliferative and Antitumor Activities (JHU ref. 1433) Artemisinin is usually administered for the treatment of multi-drug resistant malaria. However, studies ... More...   Herpes Simplex Virus Amplicon Expression in Gamma AAV  (JHU ref. 3501) HSV-1 amplicons that supply all necessary helper functions required for rAAV packaging and methods for ... More...   Purification of Serine Racemase (JHU ref. 3496) High levels of d-serine, an amino acid stereoisomer previously presumed absent in animal tissues, have ... More...   Novel Inhibitor of Programmed Cell Death (JHU ref. 1415) Apoptosis is the fundamental cellular process for the self-destruction of cells. Modulation of cell ... More...   Inducible Genetic Suppression of Excitability for Gene Therapy of Epilepsy, Cardia Arrhythmias, and Intractable Pain (JHU ref. 3451) This invention utilizes a viral expression system enabling inducible and efficient transfection of mammalian cells. ... More...   Somatic Mutations of the Mitochondrial Genome in Human Colorectal Tumours (JHU ref. 3449) Alterations of oxidative phosphorylation are play a role in cancerous growth. Mitochondria have received ... More...   Neutralization of HIV-1 by Bacterial Toxins (JHU ref. 3444) Aerolysin is a channel-forming toxin secreted by Aeromonas spp. that binds to glycosyl phosphatidylinositol ... More...   Biosynthetic Engineering of Cell Surface Sialic Acids (JHU ref. 3442) Surrounding every cell is a halo of glycoproteins, glycolipids and proteoglycans termed the glycocalyx. ... More...   Identification of the Human Fast-1 Gene (JHU ref. 3409) In Xenopus embryos, a subset of transcriptional responses to the TGF-B family of ligands is mediated ... More...   rRNA Mutagenesis (JHU ref. 3413) The ribosome is the biological machine that has evolved to generate encoded polymers. The development ... More...   HIF-1aDP, A Constitutively-Expressed form of Hypoxia-Inducible Factor 1a (JHU ref. 3416) It has previously been demonstrated that a truncation of HIF-1alpha after amino acid residue 390 results ... More...   Immortalized Human Implantation Site Intermediate Trophoblastic Cell Line, IST-1 (JHU ref. 3408) Human HPV-16 E6E7 transduced immortal implantation site cell line was established from trophoblastic ... More...   A New Human p53 Homologue (p46) (JHU ref. 3392) Since its identification as a tumor suppressor gene, p53 has become one of the most studied genes in ... More...   Cloning of a Novel Telomerase Protein from Human Cells (JHU ref. 3389) Telomerase activity is associated with human cancer and is often associated with the selection of cells ... More...   4-phenyl butyrate treatment of X-linked adrenoleukodystrophy including affected individuals of all clinical phenotypes and heterozygous female carriers (JHU ref. 3382) 4-phenylbutyrate treatment of cells from both X-ALD patients and X-ALD knockout mice results in decreased ... More...   Human Smad3 and Smad4 are Sequence-Specific Transcription Activators (JHU ref. 3383) Mounting evidence suggests that Smad proteins are required for TGFbeta signaling, but the way(s) in ... More...   SynGAP (JHU ref. 3367) The PSD-95/SAP90 family of proteins have recently been implicated in the organization of synaptic structure. ... More...   CAPON, A Protein that Binds Neuronal Nitric Oxide Synthase (JHU ref. 3360) Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is important for N-methyl-D-aspartate ... More...   A Simplified System for Generating Recombinant Adenoviruses (JHU ref. 3356) Recombinant adenoviruses provide a versatile system for gene expression studies and therapeutic applications. ... More...   High-throughput screening assay for mitochondrially-active drugs (JHU ref. 3352) Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ... More...   PP32 Related Gene (JHU ref. 3335) pp32 is the prototypic member of a family of genes whose alternative use in prostate, breast, and other ... More...   Xanthine Oidase Inhibitors as Calcium-Sensitizing Therapeutic Agents for Heart Failure (JHU ref. 3326) This invention exploits two newly discovered relationships: (1) elevated xanthine oxidase activity is ... More...   Biodegradable Ploymer Wafers Impregnated with Hybrid Analogs of 1, 25-dihydroxyvitamin D3 for the Treatment of Intracranial Metastases (JHU ref. 3301) Localized delivery of 1,25 D3 directly to a target area using biodegradable polymeric matrices maximizes ... More...   Enhanced gene delivery to myocardium promoted by changes in vasculature permeability (JHU ref. 3300) The invention relates to improved methods and compositions for in vivo intravascular gene transfer to ... More...   Use of Multivalent Chimeric Peptide-loaded, MHC/lg Molecules to Detect, Activate or Suppress Antigen-Specific, T Cell-Dependent Immune Responses (JHU ref. 3302) Antigen-specific T cells play major roles in both normal physiologic immune responses as well as in ... More...   Compound for Protection against Ischemia-Reperfusion Injury (JHU ref. 3292) An active ingredient in Chinese herbal medicine has been found to be useful for treating reperfusion ... More...   Blocker of Hedgehog Signalling (JHU ref. 3295) A Sonic hedgehog (Shh) response element was identified in the chicken ovalbumin upstream promoter-transcription ... More...   Mice with Targeted Inactivation of Presenilin 1 Gene (JHU ref. 3258) The present invention relates to a transgenic non-human animal lacking native presenilin 1 (PS1) protein ... More...   Lefty-1 (JHU ref. 3260) The present invention provides a cell growth and differentiation factor, Lefty-1, a polynucleotide sequence ... More...   Targeted Somatic Gene Transfer to Predict Drug Effects in Complex Cells and Tissues (JHU ref. 3246) The instant invention provides novel somatic gene transfer methods for mimicking one or more effects ... More...   Se-jin Lee, Thanh Huynh, Suzanne Sebald, Christopher Rankin & Edward Hsiao (JHU ref. 3245) The present invention provides a growth and differentiation factor, GDF-15, and a polynucleotide sequence ... More...   Homer Gene (JHU ref. 3237) The present invention is concerned with a novel family of proteins that are present in the mammalian ... More...   Semaphorins (JHU ref. 3235) The semaphorin gene family consists of a large family of conserved proteins several members of which ... More...   Catenin/Tcf Complexes Mediate APC-Tumor Suppression  (JHU ref. 3226) Mutations of the adenomatous polyposis coli (APC) gene are the most common disease-causing genetic events ... More...   Nitric Oxide, and Nitric Oxide Donors, as a Therapy for the Common Cold and for Virally-Induced Asthma Attacks (JHU ref. 3224) The common cold is the most frequently experienced acute respiratory illness in humans. The majority ... More...   Arachadonic Acid/Ceramide-Based Screens for Colorectal Cancer Chemopreventive Agents (JHU ref. 3214) Nonsteroidal antiinflammatory drugs (NSAIDS) can inhibit colorectal tumorigenesis and are one of the ... More...   An APC Mutation Associated with Familial Colorectal Cancer (JHU ref. 3212) Of the 160,000 new cases of colorectal cancer (CRC) diagnosed each year in the U.S., at least 15% have ... More...   CP2 Derived Regulators of Cytokine Gene Expression  (JHU ref. 3209) Therapeutic compositions that include small molecule affectors of CP2 function, particularly inhibitors ... More...   Autologous GVHD (JHU ref. 3200) Portions of the MHC class II invariant chain peptide, termed CLIP, exhibit immunomodulatory properties ... More...   A Photoreceptor Cell-Specific ATP Binding Transporter Gene (ABCR) is Mutated in Recessive Stargardt Macular Dystrophy (JHU ref. 3195) Vitelliform macular dystrophy (VMD/Best disease) is an early-onset autosomal dominant disorder in which ... More...   Isolation of GRIP (JHU ref. 3191) The invention concerns the discovery of a novel family of proteins named as glutamate receptor interacting ... More...   Oxidized Low Density Lipoproteins Stimulate Galactosyltransferase Activity, Ras Activation, p44 Mitogen Activated Protein Kinase and C-fos Expression in Aortic Smooth Muscle Cells (JHU ref. 3190) We have discovered that in human aortic smooth muscle cells oxidized low density lipoproteins(Ox-LDL) ... More...   Reversal of Loss of Imprinting in Tumor Cells by 5-aza-2"-deoycytidine (JHU ref. 3179) In order to determine whether loss of imprinting (LOI) in cancer might be reversed by altering DNA methylation, ... More...   Amino Acid Supplement for Dialysis Patients (JHU ref. 3165) A method for preventing and/or correcting hypoalbuminemia in patients on hemodialysis by adminstering ... More...   Mutations of Glutamate Transporters in Neurodegenerative Disease (JHU ref. 3151) Multiple studies have shown abnormal glutamate metabolism in patients with amyotrophic lateral sclerosis ... More...   Therapeutic use of Ligands for CD46 for treatment of patients with disorders associate patheogenetically w/inappropriate or excess production of IL-12 (JHU ref. 3139) The present invention provides a method of treating a variety of disorders in a mammal characterized ... More...   Device forTranstracheal Insufflation in Treating Obstructive Sleep Apnea (JHU ref. 3128) A novel ventilatory support system which controls the flow of breathing gas to a patient based upon ... More...   Identification of Pyrazinamide-Resistant Mycobacteria and Methods for Treating Mycobacterial Infections  (JHU ref. 1283) Conventional methods for treating tuberculosis include administration of drugs such as pyrazinamide ... More...   Discovery of Human Mad-related Genes (JHU ref. 3105) Resistance to the growth inhibitory effects of TGF-beta is common in human cancers. However the mechanism(s) ... More...   cDNA Cloning and Characterization of a Mammalian Regulator of Nonsense Transcript Stability (Rent 1) (JHU ref. 3095) All organisms that have been studied to date possess the ability to detect and degrade transcripts that ... More...   Generation of Soluble Divalent Heterodimeric Analogs of Proteins involved in Immune Responses (JHU ref. 3085) This invention is directed to compositions comprising soluble divalent and multivalent heterodimeric ... More...   AAV Gene Therapy Vector to Muscle Cells (JHU ref. 3083) The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle ... More...   An Assay for Determining Subunit Interaction in Ion Channels (JHU ref. 3082) The present invention relates to compounds and related methods for both inhibiting and potentiating ... More...   Urease-Responsive Delivery Systems for Diagnostic and Therapeutic Applications  (JHU ref. 3079) The present invention provides novel compositions and methods for diagnosing the presence of Helicobacter ... More...   Interferon Gamma-Gene-Based Therapy in Allergic Diseases (JHU ref. 3072) In vivo delivery of an interferon-y gene to mucosal cells of the lung is an effective means to treat ... More...   Converting Cancer Genes into Killer Genes (JHU ref. 3071) A new gene therapy approach has been developed which exploits the genetic alternations characteristic ... More...   Bisulfite Modified Methylation Specific PCR (JHU ref. 3057) The precise mapping of DNA methylation patterns in CpG islands has become essential for understanding ... More...   A Novel Cancer Drug Screen Based on Cell Cycle Uncoupling  (JHU ref. 3053) Precise coordination of the S and M phases of the eukaryotic cell cycle is critical not only for normal ... More...   DPC4, A Candidate Tumor-Suppressor Gene (JHU ref. 3041) The DPC4 gene is also known as SMAD4 or as MADH4. It is a mediator of signal transduction for TGFbeta, ... More...   Huntington Associated Protein (JHU ref. 3038) Proteins which specifically bind to huntingtin, the product of the Huntington's Disease locus (HD), ... More...   GDF -14 (JHU ref. 3036) The present invention provides a growth and differentiation factor, GDF-14, and a polynucleotide sequence ... More...   A Method for Designing Non-Linear Field Reflectrons (JHU ref. 3028) This is an approach to the design of reflectron time-of-flight mass analyzers that utilizes a cylindrical ... More...   Intervention in and Prevention of Epstein-Barr Virus Infection through Targeting of the EBNA2/CBF1 Interaction (JHU ref. 3002) Peptides having substantial homology with a cellular DNA-binding domain (known as CBF1/RBPJk) of the ... More...   Enhancing Nerve Regeneration (JHU ref. 3000) Compounds have been identified which can stimulate neuronal growth by inhibiting the neuronal inhibitory ... More...   HIF-1 (JHU ref. 9970) The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed ... More...   Suppressors of p53 Cancer Mutations & Genetic Assays and Strains using Human TP53 (JHU ref. 9941) The technology concerns the identification of second-site suppressor mutations that can act as Aglobal ... More...   Cloning & Characterization of Human & Murine (PP32) (JHU ref. 9878) Pp32 is a nuclear protein found highly expressed in normal tissues in those cells capable of self-renewal ... More...   GDF-12 (JHU ref. 9864) The present invention provides a growth and differentiation factor, GDF-12 and a polynucleotide sequence ... More...   A New Tumor Suppressor Gene (JHU ref. 9856) A new tumor suppressor gene, HIC-1, has been found. Abnormal DNA methylation of a CpG island, which ... More...   Transcription Factor for MHC Class II Genes (JHU ref. 9827) The major histocompatibility complex (MHC) class II molecules function in presenting processed peptides ... More...   Occlusion of Subretinal Vascular Beds by Laser Targeted Photodynamic Therapy  (JHU ref. 9819) The methods and materials in this invention relate to selective and non-invasive visualization, or treatment ... More...   Human Sphingomyelinase (JHU ref. 9810) JHU inventors- have isolated, -purified and cloned a human neutral sphingomyelinase that cleaves sphingomyelin ... More...   Growth Differentiation Factor-11(GDF-11) (JHU ref. 9805) The TGF-.beta. superfamily consists of multifunctional polypeptides that control proliferation, differentiation, ... More...   Hedgehog Gene (JHU ref. 9765) The present invention is based on the seminal discovery that hedgehog proteins undergo autoproteolytic ... More...   GDF-10 (JHU ref. 9759) The present invention provides a growth and differentiation factor, GDF-10 and a polynucleotide sequence ... More...   Packaging Recombinant Adeno-Associated Virus Vector  (JHU ref. 9737) Adeno-associated virus (AAV) vectors may have utility for gene therapy but heretofore a significant ... More...   Microencapsulation of Living Cells By Biopolymers (JHU ref. 9716) The invention relates to living cells encapsulated in a membrane. The membrane is a complex formed by ... More...   Microencapsulation of Living Cells By Biopolymers (JHU ref. C09716) The invention relates to living cells encapsulated in a membrane. The membrane is a complex formed by ... More...   Use of Botulinum Toxin for Treatment of Smooth Muscle Disorder (JHU ref. 9674) Direct injection of sphincteric botulinum toxin is disclosed as an effective, safe and simple method ... More...   Use of Retinoic Acid (JHU ref. 9677) Proliferation of retinal pigment epithelium following surgery or trauma is prevented by contacting retinal ... More...   Protein Useful in Diagnosing Cancer (JHU ref. 9651) This technology includes a nuclear matrix protein PC-1 (prostate cancer-1) which is expressed only in ... More...   Growth/differentiation factor-6 (GDF-6) (JHU ref. 9603) The present invention provides a growth and differentiation factor, GDF-6 and a polynucleotide sequence ... More...   Growth/differentiation factor-7 (GDF-7) (JHU ref. 9604) The present invention provides a growth and differentiation factor, GDF-7 and a polynucleotide sequence ... More...   Molecular Cloning of Macrophage Nitric Oxide Synthase (JHU ref. 9563) We now report the molecular cloning of macrophage NOS. The macrophage enzyme displays 50% sequence identity ... More...   Growth/Differentiation Factor-3 (GDF-3) (JHU ref. 9571) The present invention provides a cell growth and differentiation factor, GDF-3, a polynucleotide sequence ... More...   Growth/Differentiation Factor-9 (GDF-9) (JHU ref. 9573) The present invention provides a growth and differentiation factor, GDF-9 and a polynucleotide sequence ... More...   Growth/Differentiation Factor-5 (GDF-5) (JHU ref. 9572) The present invention provides a growth and differentiation factor, GDF-5 and a polynucleotide sequence ... More...   Role of Nitric Oxide Synthase in Penile Erection (JHU ref. 9567) Methods and devices are taught for regulating penile erection and urethral function. Inhibitors of nitric ... More...   Chronic Endothelial Cell Culture Under Flow (JHU ref. 9548) An in vitro method for producing a device coated with adherent cells by utilizing shear stress is provided. ... More...   Xenograft Tolerance  (JHU ref. 9538) This invention provides a method for developing immune tolerance in xenogeneic organ graft recipients, ... More...   Olfactory Facilitation by Selective Inhibition of Olfactory Calcium/Calmodulin Activated Phosphodiesterase (JHU ref. 9454) The present invention provides simple methods for enhancing the sense of smell. The methods involves ... More...   Methods for Treatment of Free-Radical-Mediated Tissue Injury (JHU ref. 9447) Methods for treatment of free-radical-mediated tissue injury, particularly sepsis, are provided wherein ... More...   Anti-viral Target For Herpes Virus (JHU ref. 9420) A herpes virus proteinase has been identified and cloned from cytomegalovirus. The substrate for the ... More...   Characterization of CoA-independent transacylase activity in U-937 cells (JHU ref. 9393) A novel method of treating inflammatory disease in a mammal by administering to the mammal an effective ... More...   Advantages of Insulin Delivered as an Aerosol Through the Lungs (JHU ref. 9382) A method of delivering a protein, in particular insulin, to the lungs. The method is characterized in ... More...   MIG2 (JHU ref. 9370) A new member of the chemokine family of cytokines has been identified. These chemokines are produced ... More...   Establishment of a Human Cerebral CortexCell Line (JHU ref. 9272) This invention consists of a continuous, non-malignant, neuronal cell line, the cells of which: a) in ... More...   Regional Chemotherapy with 4-Hydroperoxycyclophosphamide (Intrathecal Administration)  (JHU ref. 9258) A method of treating human tumors is provided in which tumors are regionally treated with a cytolytic, ... More...   A Neutral Glycolipid as an Adsorbent forEnteric Viral Pathogens (JHU ref. 9244) The binding of neutral glycolipid (asialo-GM1) to a broad spectrum of enteric viruses is taught. The ... More...   Monoclonal Antibodies Against Leukocyte Adhesion Receptor Beta-Chain, Methods of Producing These Antibodies and Use Therefore (JHU ref. 9214) Monoclonal antibodies with specificity for leukocyte adhesion receptor (LAR) beta-chain are provided. ... More...   Method of Retarding the Progression of Chronic Renal Failure (JHU ref. 9217) Progression of chronic renal failure can be retarded (slowed or arrested) by administering to humans ... More...   The Human C3b/C4b Receptor (CR1) (JHU ref. 9171) The present invention relates to the C3b/C4b receptor (CR1) gene and its encoded protein. The invention ... More...   cDNA Cloning and Sequencing of Peptidyl-Glycine Alpha-Amidating Monooxygenasse (JHU ref. 2285) The sequence of bovine PAM is taught as well as new forms of PAM not known before. One new form is membrane ... More...   Anti-Viral and Immunostimulatory Polynucleotide Duplex and Use Thereof  (JHU ref. 1068) Genital herpes is a viral disease affecting an estimated 45 million Americans. Current reports indicate ... More...   Therapeutic Suppression of Specific Immune Responses by Administration of Oligomeric Forms of Antigen of Controlled Chemistry (JHU ref. 2179) The method and construct used to reduce undesired antibody response in a mammal by administering a non-immunogenic ... More...   NOVEL RETINOID-INDUCIBLE GENE INVOLVED IN SPINAL MOTOR NEURON DIFFERENTIATION (JHU ref. 4585) During neural development, regulation of cell-cycle and differentiation is essential for cell-fate specification, ... More...   IMMEDIATE EARLY GENE THAT PLAYS A ROLE IN EARLY-ONSET FAMILIAL ALZHEIMER’S DISEASE (JHU ref. 4579) Presenilins are polytopic transmembrane (TM) proteins. Mutations in presenilins are associated with ... More...   ROLE OF EXTRA-CELLULAR MATRIX PROTEINS AS INFLAMMATION MODULATORs (JHU ref. 4946) Many biological processes affect the host’s ability to recognize pathogens, mount an innate immune response ... More...   METHOD TO IMPROVE CONTRACTILE FUNCTION AND METABOLISM IN HEART FAILURE (JHU ref. 4969) Cardiac contraction generates the pumping action of the heart, while chemical energy derived from heart ... More...   Glutamate Modulation as Prophylactic Neuroprotective Therapy for Radiation Induced Injury and as Radiosensitizer for Treatment of Brain Tumors (JHU ref. 4966) Ionizing radiation is an essential part of the treatment of many types of central nervous system tumors ... More...   PROMOTERS FOR NEURAL REGENERATION (JHU ref. 4904) Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited ... More...   ROLE OF ION CHANNELS IN NEURAL PROTECTION AND REGENERATION (JHU ref. 4986) Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited ... More...   CSF IL-6 as a Biomarker and Prognostic Marker in Inflammatory Disorders of the Nervous System (JHU ref. 5013) The present invention relates to soluble immune derangements in the cerebrospinal fluid of patients ... More...   A Novel Regulator of Cytochrome P450 Enzymes (JHU ref. 5023) This invention describes the discovery of a novel gene whose gene product binds to cytochrome P450 enzymes ... More...             Home | Legal | Site Credits