Biological Sciences : Diagnostics Pancreatic Cancer Susceptibility Gene as a Biomarker and Therapeutic Target  (JHU ref. C10674) BACKGROUND Pancreatic cancer is a malignant tumor. Each year ~250,000 people worldwide and ~ 38,000 ... More...   Improved Method of Infective Fungal Species Typing (JHU ref. C10633) Aspergillosis is a major cause of invasive mold infections in immune-compromised patients. Fungal infections ... More...   Global Genetic Alterations Analysis & Novel Diagnostic/Therapeutic Biomarkers for Breast and Colorectal Cancer (JHU ref. C10471) BACKGROUND It is well accepted that cancer is the result of the sequential mutations of oncogenes ... More...   Molecular Target to Diagnose & Treat Pancreatic Cancer & Methods to Identify New Targets (JHU ref. C10569) BACKGROUND Pancreatic cancer is a malignant tumor of the pancreas. Each year ~250,000 people worldwide ... More...   Identification of immune regulatory targets in ovarian cancer (JHU ref. C10565) Ovarian cancer ranks fifth highest as the cause of cancer-related deaths among females and has the highest ... More...   Novel Biomarkers and Therapeutic Targets for Melanoma (JHU ref. C10223) Melanoma is a potentially life-threatening form of skin cancer whose incidence is increasing at the ... More...   Novel Epigenomic Biomarkers for Breast Cancer (JHU ref. C10643) BACKGROUND: Breast cancer is the leading cause of cancer death among women worldwide. According ... More...   Serum-based assay for prostate cancer detection (JHU ref. C10443) Prostate cancer is the second leading cause of cancer death in men in the United States. The currently ... More...   MethySYBR: PCR Assay for Quantitative and Melting Curve Analyses of Methylated Alleles (JHU ref. C10429) Aberrant methylation patterns play multiple roles in cancer, such as the silencing of tumor suppressor ... More...   Clinical biomarkers for adverse aging-related outcomes (JHU ref. C10411) It is a known fact that number of people over the age of 65 is growing and, therefore, growing the necessity ... More...   Monoclonal Antibody to Pfalciparum Aldolase (Hybridoma Clone PVALD 434-3 4A4.2E12 or PVALD 434-3 4A4.6B10) (JHU ref. C10647) Malaria is severe disease and caused by a parasite called Plasmodium. According to the World Health ... More...   Diagnostic & Prognostic Biomarkers for Cutaneous Squamous Cell Carcinoma (JHU ref. C10619) Cutaneous squamous cell carcinoma (SCC) is the second most common type of skin cancer. More than 1 million ... More...   BEAMING and Improvements (JHU ref. C10425) Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), ... More...   Genetic Biomarkers for Prognosis of Acute Lung Injury Patient Outcome (JHU ref. C10423) Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), a more severe form of ALI are ... More...   Serum Biomarkers for detection of Barrett’s Esophagus and Esophageal Adenocarcinoma (JHU ref. C10106) JHU scientists discovered multiple serum protein-based biomarkers for the detection of BE and EAC using ... More...   Biomarkers for Breast Cancer Stem Cells (JHU ref. C10452) Breast cancer is the leading cause of cancer death among women worldwide. There were 1.3 million new ... More...   Easily Detectable Diagnostic Biomarker of Fungal Infection (JHU ref. C10606) Aspergillosis, the most common filamentous fungal infection, carries a high mortality rate due to diagnostic ... More...   Peptide Based Inhibitors of PSA (JHU ref. C10238) Prostate cancer is the leading cancer for men in the United States, accounting for 25% of all new cancer ... More...   New PSMA-targeting reagent for SPECT imaging (JHU ref. C10635) JHU scientists have synthesized a new prostate-specific membrane antigen (PSMA) targeting reagent for ... More...   New PSMA-targeting reagent for PET imaging (JHU ref. C10636) JHU scientists have synthesized a new prostate-specific membrane antigen (PSMA) targeting reagent for ... More...   Resilient Genetic Biomarkers in Bile for Diagnosis of Liver, Pancreatic, and Biliary Tree Cancers (JHU ref. C10653) Liver cancer, pancreatic cancer and biliary tree cancer are devastating diseases with dismal survival ... More...   Complement Factor Expression Linked to Susceptibility to Flavivirus Infections (JHU ref. C10625) Dengue fever is an acute insect-borne viral disease that can worsen into life-threatening dengue hemorrhagic ... More...   Specific MicroRNA Biomarkers for Cholangiocarcinoma Early Diagnostic Assays (JHU ref. C10621) Cholangiocarcinomas (CCA) are aggressive cancers of the bile duct system with dismal survival rates. ... More...   Novel Diagnostic/ Prognostic Biomarker and Method for Rheumatoid Arthritis  (JHU ref. C04781) Current serological markers for RA diagnosis are non-specific and are influenced by comorbid conditions, ... More...   Novel Human alpha7 Nicotinic Acetylcholine Receptor Subunit Splice Variants (JHU ref. C04883) Abnormal alpha7 nicotinic acetylcholine receptor activity contributes to sensory gating and cognitive ... More...   Collagen Mimetic Peptides for Imaging and Therapy (JHU ref. C10462) Collagens, the most abundant protein in mammals, provide a structural framework during tissue development ... More...   Biomarkers for Pancreatic and Biliary Cancers (JHU ref. C10090) Pancreatic and biliary cancers are two of the most fatal among all human malignancies. Late presentation ... More...   Diagnostic Biomarkers of Kidney Transplant Dysfunction (JHU ref. C10419) JHU scientists screened patient samples with known delayed graft function (DGF) and acute tubular necrosis ... More...   Radiolabeled Inhibitors for Prostate Cancer Imaging & Therapeutics (JHU ref. C10098) Prostate-specific membrane antigen (PSMA) is a cell surface protein that is over expressed in prostate ... More...   Solar Cells Incorporating Light Harvesting Arrays (JHU ref. C01616) A solar cell incorporates a light harvesting array that comprises: (a) a first substrate comprising ... More...   Cost-Effective Method for High-Throughput and Quantitative Analysis of DNA Methylation (JHU ref. C10249) Investigators at Johns Hopkins University developed a simple and cost-effective approach to detect and ... More...   A Predictive Test for Determining Chemotherapy Regimens in Patients with Cancer (JHU ref. C10317) The ability to predict sensitivity to individual cytotoxic chemotherapies could improve treatment response ... More...   Genomewide Analysis of Chromosomal Translocation (JHU ref. C10160) The cancer genome is quite unstable with many aberrant genetic translocations dispersed across its sequence. ... More...   Diagnostic and Prognostic Markers and Treatment Strategies for Multiple Sclerosis (JHU ref. C04371) To date, there are no definitive biomarkers to assist clinicians in the diagnosis of multiple sclerosis ... More...   Monoclonal Antibodies (AE-1) Specific for Cytoskeletal Proteins useful for Tumor Diagnosis (JHU ref. C01192) JHU scientists have recently developed three monoclonal antibodies designated (AE1, AE2 and AE3) to ... More...   Methods and Use of Labeling Cells with X-ray and Ultrasound-visible Agents (JHU ref. C10065) Cell tracking has found major applications in immune and stern cell therapy. This is commonly done with ... More...   Cystic Fibrosis bronchial epithelial cell line S9 (JHU ref. C04772) Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 ... More...   Enhanced Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma (JHU ref. C04977) Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key ... More...   Melanoma Metastasis-associated Genes As Novel Diagnostic and Prognostic Markers and Therapeutic Targets For Melanoma (JHU ref. C05041) The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States ... More...   MicroRNA Enhancement and Inhibition of Astroglial Glutamate Transporter  (JHU ref. C10255) JHU inventors have identified a population of microRNA (miRNA) associated with a critical neurotransmitter ... More...   Diagnostic Tool for Diagnosing Benign Versus Malignant Thyroid Lesions (JHU ref. C04567) Thyroid cancer represents 1% of all malignant diseases and it is estimated that 5-10% of the population ... More...   Methylated CpG Island Amplification (MCA) (JHU ref. C03453) Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation ... More...   Screening method to predict donor organ function after transplantation (JHU ref. C10402) Transplantation represents an established procedure in end-stage organ failure patients and results ... More...   Diagnosis, Prevention and Treatment of Eye Injury and Infection (JHU ref. C10102) According to the World Health Organization, cataracts are the leading cause of blindness in the world. ... More...   Diagnostic, Prognostic, and Therapeutic Biomarkers for Heart Injury, Cardiac Stem Cell Regeneration, and the Facilitation of Patient Recovery  (JHU ref. C10224) Stem cells hold the promise to revolutionize future reparative medicine through the development of stem ... More...   Apparatus and Method for Exercising and Measuring Strength of a Patient's Limb (JHU ref. C01275) An apparatus for measuring the strength of and for performing physical therapy exercises to strengthen ... More...   Volatile Biomarkers for Analysis of Hepatic Disorders (JHU ref. C01391) The present invention features test systems and methods for detecting a hepatic disorder in a mammal ... More...   BDNF Polymorphism and Association with Bipolar Disorder (JHU ref. C03869) Johns Hopkins University scientists have determine diagnostic and therapeutic methods for neuropsychiatric ... More...   Association of Dopamine Beta-Hydroxylase Polymorphisms with Bipolar Disorder (JHU ref. C03911) A central role for the gene encoding dopamine beta-hydroxylase in neuropsychiatric disorders has been ... More...   Variant Gene Increases Risk of Type 2 Diabetes (JHU ref. C10068) Type II Diabetes Mellitus (T2DM) represents a major global health challenge with over 170 million people ... More...   Human BARX2 Gene (JHU ref. C03545) JHU scientists have discovered that the gene encoding BarH-like homeobox 2 protein (Barx2) is unexpectedly mutated in ovarian cancer. More...   Microarray analysis for Diagnosis of Barrett’s Esophagus and Esophageal Adenocarcinoma  (JHU ref. C10388) JHU scientists have discovered independent microRNA specific for Barrett’s esophagus (BE) and Esophageal ... More...   Detection of Virus Exposure as an Etiological Agent in Patients with Sudden Onset of Psychosis  (JHU ref. C10293) JHU scientists have developed an assay based on detection of certain viral antigens in patients with ... More...   Protein Expression Markers for the Detection of Thyroid Cancer Metastasis (JHU ref. C10120) Approximately 80% of all thyroid cancers are papillary thyroid carcinomas (PTCs). Correct staging of ... More...   Methylation Biomarkers in the Prediction of Barrett's Esophagus Neoplastic Progression (JHU ref. C10304) The technology includes eight methylated biomarkers characteristic of a progressive esophageal lesion ... More...   Novel Biomarkers for Autoimmune Disease (JHU ref. C10145) JHU scientists have identified biomarkers specific for autoimmune disease. Systemic autoimmune diseases ... More...   Early Diagnosis of Esophageal Cancer in Morphologically Normal Tissue Samples (JHU ref. C10435) Esophageal adenocarcinoma (EAC) is a lethal disease with 5-year survival rates of only 10-20%. Worldwide, ... More...   Identification of a Novel Vertebrate-specific chaperone, BBS12, That Causes Bardet-Biedl Syndrome (JHU ref. C05189) Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder that occurs in approximately 1in 150,000 ... More...   Protein Expression Markers for the Detection of Thyroid Cancer Metastasis (JHU ref. C10120) Approximately 80% of all thyroid cancers are papillary thyroid carcinomas (PTCs). Correct staging of ... More...   Biomarker for Severity of Sleep Disordered Breathing, Including Obstructive Sleep Apnea (JHU ref. C10006) Sleep Disordered Breathing ("SDB"; including Obstructive Sleep Apnea) is now firmly established as a ... More...   Diagnosis and Treatment of Cardiac Allograft Vasculopathy with Uric Acid Levels and Enzymatic Inhibitors  (JHU ref. C04738) JHU scientists have developed a method to predict and prevent a condition that is a serious complication ... More...   N-Methyl-D-aspartate (NMDA) Receptor NR1 Subunit Polyclonal Antibody (JHU ref. C03958) JHU scientists have developed a polyclonal antibody to the NR1 Subunit of the N-Methyl-D-aspartate (NMDA) Receptor. More...   Real-time, Non-invasive Imaging Method for Mycobacterium Tuberculosis Infection (JHU ref. C10401) Tuberculosis (TB) is one of the leading infectious causes of morbidity and mortality worldwide. Experts ... More...   Spinal Vertebral Interventions by Natural Orifice Translumenal Endoscopic Surgery (NOTES) (JHU ref. C10333) Vertebral spine procedures are currently performed via thoracoscopy and other percutaneous approaches. ... More...   Multiple Novel Hormone Receptor Variants as Biomarkers and Therapeutic Targets for Hormone Independent Human Prostate Cancer (JHU ref. C10305) Prostate cancer is a prevalent disease in aging males and is sensitive to androgen deprivation, the ... More...   A New In Vitro Assay For Evaluating Anti-viral Drug Activity (JHU ref. C10347) JHU scientists have developed an efficient in vitro single-round virus infectivity assay with a high ... More...   A Sensitive Screening Test for Early Detection of Head and Neck Cancer (JHU ref. C10294) The Johns Hopkins University is seeking commercial partners to develop a sensitive screening test for ... More...   A Novel Therapeutic and Diagnostic Modality in Human Cancer (JHU ref. C10107) Epithelial cancers (carcinomas) make up approximately 85% of all cancers and utilize a variety of strategies ... More...   Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity (JHU ref. C10100) A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing ... More...   Detection of Prostate Cancer Proteins in Serum for Cancer Diagnosis with a Blood Test (JHU ref. C10088) There is a crucial need of discovering novel biomarkers to improve the specificity of clinical diagnosis ... More...   Seventy Two Gene Model for 8 Thyroid Tumor Types (JHU ref. C10073) Thyroid cancer represents 90% of all neuroendocrine malignancies with an estimated annual incidence ... More...   Head & Neck Squamous Cell Carcinoma an Non-Small Cell Lung Cancer Prognostics and Diagnostics (JHU ref. C10070) Epigenetic changes have been implicated in the pathogenesis of solid tumors and almost all types of ... More...   Genetic Testing of Telomere-associated Genes in Dyskeratosis Congenita and Related Disorders (JHU ref. C10038) Pulmonary Fibrosis involves scarring of the lung where air sacs of the lungs become replaced by fibrotic ... More...   DNA Methylation for Diagnosic and Prognostic Determination in Prostate Cancer (JHU ref. C10007) Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. Biochemical ... More...   A New Tumor Suppressor Gene (JHU ref. C09856) A new tumor suppressor gene, HIC-1, has been found. Abnormal DNA methylation of a CpG island, which ... More...   Multivariate Statistical Modeling Biomarkers as Predictors of Recurrence Following Radical Prostatectomy (JHU ref. C09828) A method for screening individuals at risk for prostate cancer progression is disclosed. The method ... More...   Invention Relating to Prostatic Cancer (JHU ref. C09797) The isolation and characterization of a metastasis tumor suppressor gene KAI1 is disclosed and diagnostic ... More...   Novel Drugs That Can Induce EBV Lytic Infection as a Potential Therapy for EBV Associated Tumor or To Assist in Diagnostic Imaging (JHU ref. C05163) Epstein Barr Virus (EBV) is a human gamma herpes virus that can establish either a latent or lytic infection ... More...   Reversal of Aberrant Cancer Gene Silencing By Inhibition of SIRT1 (JHU ref. C05108) The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in ... More...   Method of Identifying Patients Suitable for High-Dose Cyclophosphamide Treatment (JHU ref. C05071) Aldehyde dehydrogenases (ALDHs) are intracellular enzymes responsible for oxidizing aldehydes. A number ... More...   The Consensus Coding Sequences of Breast and Colorectal Cancers (JHU ref. C05042) Human cancer is a disease caused by an accumulation of mutations in genes involved in cell cycle regulation. ... More...   High throughput generation of water-in-oil emulsions for molecular genetic analyses (JHU ref. C05006) Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), ... More...   Targeting of Stat-3 Signaling in the Hematopoietic System Evokes Multicomponent Therapeutic Antitumor Immunity (JHU ref. C04665) The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends ... More...   Mutational analysis of the tyrosine phosphatome in colorectal cancers (JHU ref. C04435) JHU researchers have performed a comprehensive mutational analysis of the protein tyrosine phosphatases ... More...   Mutations of the PIK3CA Gene in Human Cancers (JHU ref. C04407) Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important ... More...   BRAF Mutation Occurs in a Majority of Papillary Thyroid Carcinoma (JHU ref. C04213) The BRAF gene was recently found to be activated by mutation in human cancers, predominantly in malignant ... More...   Digital Karyotyping (JHU ref. C04154) Alterations in the genetic content of a cell underlie many human diseases, including cancers. A method ... More...   Mutations in Macrophage Scavenger Receptor 1 Gene Increase Risk of Prostate Cancer, Asthma, and Cardiovascular Disease (JHU ref. C04022) The present invention discloses methods of screening a subject for increased likelihood or risk of certain ... More...   Molecular Characteristics of Non-small Cell Lung Cancer (JHU ref. C03957) We used hierarchical clustering to examine gene expression profiles generated by serial analysis of ... More...   Novel Genes of Kaposi's Sarcoma Associated Herpesvirus (Human Herpesvirus Eight) (JHU ref. C03120) Karposi sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is a virus commonly occurring ... More...   An Epithelial Protein and DNA Thereof For Use in Early Cancer Detection (JHU ref. C01323) The present invention is a purified and isolated epithelial protein, peptide and variants thereof whose ... More...   Early Detection of Lung Cancer Treatment (JHU ref. C01106) The present invention relates to a method for early detection of lung cancer. The method comprises obtaining ... More...   Detection of Prostate Cancer Proteins in Serum for Cancer Diagnosis with a Blood Test (JHU ref. 10088) There is a crucial need of discovering novel biomarkers to improve the specificity of clinical diagnosis ... More...   Biomarker for Severity of Sleep Disordered Breathing, Including Obstructive Sleep Apnea  (JHU ref. 10006) Sleep Disordered Breathing ("SDB"; including Obstructive Sleep Apnea) is now firmly established as a ... More...   An Assay to Identify Novel Targets and Personalize Combination Anticancer Therapy  (JHU ref. 5174) Scientists at JHU have developed a pharmacodiagnostic assay to identify relevant targets and direct ... More...   Biomarkers for Chemo-resistance in Ovarian Cancer (JHU ref. 10010) Ovarian cancer is the most lethal gynecologic malignancy in the US. Although it is initially very responsive ... More...   Method for imaging cannabinoid receptor type 1 (CB1) using radiolabeled 4-cyano-1,5-diphenyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamides  (JHU ref. 5025) Radioligand development for Positron emission tomography imaging of the cerebral cannabinoid receptor ... More...   Development of a Biomarker for the Early Detection of Diabetes ("Pre-Diabetes") based Upon O-GIcNAc (JHU ref. 5104) JHU scientists have identified markers in human blood that might readily identify individuals at the ... More...   MicroRNA-based Diagnostic Testing and Therapies for Inflammatory Bowel Disease (JHU ref. 5191) Ulcerative colitis (UC) and Crohn's disease (CD) are the two most common chronic inflammatory bowel ... More...   Proteins involved in pulmonary, cardiac and inflammatory disorders (JHU ref. 4858) Scientists at JHU have discovered a novel protein and its related family members and receptors. The ... More...   CanScript for Gene Therapy: A DNA enhancer element conveying cancer-specific expression to 30% of human malignancies (JHU ref. 5183) One of the major requirements for effective cancer gene therapies are DNA sequences that, when inserted ... More...   Quantitative Detection of Promoter Hypermethylation as a Biomarker of Acute Kidney Injury During Transplantation. (JHU ref. 5153) Kidney repair after injury is a recapitulation of normal morphogenesis, with similarities to malignant ... More...   A Functional Assay Distinguishing Pathogenic and Nonpathogenic Variant Alleles of the BRCA2 Gene  (JHU ref. 5150) Some inherited mutations that inactivate BRCA2 and cause a high familial risk of breast, ovarian, and ... More...   Generation of Xenografts on Mice to Tailor Anticancer Therapy from Fine Needle Aspiration Biopsies (JHU ref. 5107) Xenografts can be made from resected tumors of pancreatic cancer patients in order to generate tumor ... More...   Sensitive Assay to Detect HIV neurotoxic proteins and Antibodies in Spinal Fluid  (JHU ref. C05087) Johns Hopkins University is currently seeking licensees for an innovative method to detect toxic HIV ... More...   Method of Identifying Patients Suitable for High-Dose Cyclophosphamide Treatment (JHU ref. 5071) Aldehyde dehydrogenases (ALDHs) are intracellular enzymes responsible for oxidizing aldehydes. A number ... More...   Identification of Staphylococcal Enterotoxin-B (SEB) Sequences Involved in Cell Proliferation and Cell Death (JHU ref. C05048) Studies suggest that staphylococcal enterotoxin B (SEB) is initially harbored in the kidney by binding ... More...   Melanoma Metastasis-Associated Genes as Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma (JHU ref. 5041) The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States ... More...   The Consensus Coding Sequences of Breast and Colorectal Cancers (JHU ref. 5042) Human cancer is a disease caused by an accumulation of mutations in genes involved in cell cycle regulation. ... More...   High throughput generation of water-in-oil emulsions for molecular genetic analyses (JHU ref. 5006) Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), ... More...   Alteration of the Albumin-bound Protein/peptide Complex (ABPPC) is Biomarker for Disease (JHU ref. 4997) JHU scientists have invented a cost-effective, rapid, and sensitive assay that characterizes proteins ... More...   Enhanced Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma (JHU ref. 4977) Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key ... More...   A rapid assay using Fine Needle Aspiration (FNA) to test for 5-fluorouracil dosing and efficacy (JHU ref. 4947) Scientists at JHU have developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil ... More...   Discovery of a novel oncogene involved in breast cancer (JHU ref. 4936) TGF-beta signal transduction is a primary tumor suppression pathway in breast cancer. Many breast cancer ... More...   HOXB7 as a Potential Prognostic Marker and Therapeutic Target in Cancer (JHU ref. 4922) Scientists at The Johns Hopkins University have determined that HOXB7, a member of homeobox superfamily ... More...   Mycobacterial Catalase-peroxidase in the Diagnosis and Treatment of Sarcoidosis (JHU ref. 4915) Sarcoidosis is an organ-wide inflammatory disease of unknown etiology that is characterized by the presence ... More...   Chest Pain Differentiation Serum Diagnostic Panel (JHU ref. 4903) Patients presenting at an emergency room with acute chest pain are likely to be evaluated for acute ... More...   Compounds with effects on potassium channels (JHU ref. 4902) KCNQ channels play a role in cardiac and neuronal membrane excitability. Scientists at JHU have identified ... More...   BEAMing up: Improvements in BEAMing Process for the Detection of Rare Mutations (JHU ref. 4862) Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), ... More...   A new method to increase memory T lymphocytes using a monoclonal antibody (JHU ref. 4819) CD137 has long been recognized as a co-stimulatory receptor for growth and functional maturation of ... More...   A method for functionally activating the ion channel Transient Receptor Potential Vanilloid Subtype 3 and screening for antagonists and modulators of this channel protein (JHU ref. 4565) The nonselective cation channel, TRPV3, can be gated by temperatures greater than ~32°C and may play ... More...   Microarray Gene Expression Profiling of IBD Endoscopic Biopsy Tissues and Identification of Biomarkers (JHU ref. 4543) This invention relates to the identification of biomarkers for ulcerative colitis (UC) and Crohn's disease ... More...   Novel Diagnostic & Prognostic Markers & Therapeutic Targets for melanoma (JHU ref. 4578) The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States ... More...   Total Human Serum Free IgE Immunoenzymetric Assay (IEMA) (JHU ref. 4700) Xolair (generic name, omalizumab) is currently approved by the FDA for the treatment of extrinsic asthma. ... More...   Point-of-Care Mass Spectrometer (JHU ref. 4527) The invention is an apparatus for clinical diagnostics using a point-of-care approach to mass spectrometry ... More...   BRAF Mutation Occurs in a Majority of Papillary Thyroid Carcinoma  (JHU ref. 4213) The BRAF gene was recently found to be activated by mutation in human cancers, predominantly in malignant ... More...   Test for Colon Cancer Adenoma Formation Risk and Possibly Risk of Other Tumor Type Formation (JHU ref. 4482) This invention provides a strategy for identifying patients at risk of colorectal cancer, and likely ... More...   Diagnostic and Prognostic Markers and Treatment Strategies for Multiple Sclerosis (JHU ref. 4371)  The invention is the discovery of novel protein biomarkers associated with Multiple Sclerosis. More...   Method and Kit for Diagnosis and Drug Screening Towards Psychiatric Disorders  (JHU ref. 4397) This invention relates to a method and kit for diagnosis and drug screening towards psychiatric disorders. ... More...   Mutations of the PIK3CA Gene in Human Cancers  (JHU ref. 4407) Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important ... More...   Imaging Bacteria with Light-emitting Substrates of Thymidine Kinase  (JHU ref. 4488) JHU researchers describe a simple and specific method for imaging bacteria using light-emitting substrates ... More...   A Novel Method for Quantitatively Analyzing Multiple Genes for the presence of Methylation in Biological Samples (JHU ref. 4348) Extreme sensitivity is needed in a test to detect breast cancer in samples with little cellularity. ... More...   Antibody to Human DNA Methyltransferase 1 (JHU ref. 4328) We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human ... More...   Urine Biochemical Markers of Delayed Graft Function Based on Molecular Mass Peaks. (JHU ref. 4298) Delayed Graft Function (DGF) constitutes a major impediment to the success of solid organ transplant. ... More...   Transforming Single DNA Molecules into Fluorescent Magnetic Particles for Detection and Enumeration of Genetic Variation (JHU ref. 4273) Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), ... More...   SPARC/osteonectin is a Frequent Target for Aberrant Methylation in Pancreatic Adenocarcinoma (JHU ref. 4245) Deregulated expression of SPARC/osteonectin, a secreted glycoprotein with multiple biological functions, ... More...   Identifying Tumor Origin Using a Gene Expression Based Classification Map  (JHU ref. 4235) Identifying the primary site in cases of metastatic carcinoma of unknown origin has profound clinical ... More...   Extracellular PSMA Fusion Protein, Recombinant Baculovirus, and Plasmid Vectors (JHU ref. 4232) The invention provides the means to purify large quantities of a fusion protein containing the entire ... More...   Novel Tyrosine Kinases Implicated in Colorectal Cancers (JHU ref. 4145) Tyrosine kinases (TK) are the regulators of signaling pathways that control cellular functions such ... More...   Tumor Antigen Identification (JHU ref. 4158) The process of granzyme B proteolysis has been implicated in the selection of autoantigens by the autoimmune ... More...   Design and Synthesis of Renal Dipeptidase Inhibitors (JHU ref. 4094) Colon cancer is a deadly disease with a 6% average lifetime risk in the United States. When detected ... More...   A Nucleotide Factor Kappa-B Promoter Polymorphism is associated with Increased Risk For Ulcerative Colitis (JHU ref. 4062) We have been investigating genes that are associated with inflammatory bowel disease. Recently, we ... More...   Functional Variants of Klotho associate with human longevity and contribute to the acquisition of age-related phenotypes  (JHU ref. 3976) It is known in the art that mice deficient in Klotho gene expression exhibit a syndrome resembling human ... More...   Identification of DNA Sequences Differentially Methylated in Pancreatic Cancer (JHU ref. 3825) Researchers at Johns Hopkins University have used the techniques of methylated CpG island amplification ... More...   Methods for Identifying Gene Regulatory Sequences, and the Identity of such Sequences (JHU ref. 3779) A barrier to advances in understanding the mechanisms and regulation of imprinting of a genomic region ... More...   A Novel Rapid Quantitative Assay for the Simultaneous Detection of Microbial Infection and Speciation (JHU ref. 3772) Current methods for determining whether a patient has a bacterial infection are time-consuming and may ... More...   Mutation Detection of Entire Duplicated Part of PKD1 in Genomic DNA Sample (JHU ref. 3708) Given the abundance of PKD1 families, the clinical and scientific impact of mutation studies, and the ... More...   Establishing Genomic Imprinting by Cell Differentiation: A Model System Using Embryonic Germ Cells (JHU ref. 3704) The purpose of the invention is to develop the first in vitro model system for studying genomic imprinting. ... More...   Intronic, Exonic and Regulatory Single Nucleotide Polymorphisms in the Human Surfactant Protein B Gene (JHU ref. 3674) Single nucleotide polymorphisms (SNPs) associated with surfactant protein B deficiency and respiratory ... More...   Monoclonal Antibodies to Gangliosides Raised in Ganglioside-Deficient Knockout Mice (JHU ref. 3663) Knock-out mice lacking complex gangliosides were found to be improved hosts for raising high affinity, ... More...   A Visual Color Detection System to Identify Agents that Induce Mitochondrial Dysfunction. (JHU ref. 3583) Mitochondrial dysfunction can lead to many diseases and can effect any organ at any age. The number ... More...   Aerolysin as a Diagnostic Test for Paroxysmal Nocturnal Hemoglobinuria (JHU ref. 3426) This invention relates to the discovery that certain biological toxins specifically bind to the glycosylphosphatidylinositol ... More...   Mechanisims Underlying DPC4 Transcriptional Defects in Cancer Cells (JHU ref. 3435) Enforced nuclear relocalization of DPC4/Smad4. The direct control of nuclear localization of the tumor-suppressor ... More...   A Method for Detection of Cancer and/or Risk of Cancer Based on Loss of Imprinting (JHU ref. 3418) At present, genetic testing is able to detect only a small fraction of the population at risk of cancer. ... More...   Macroscopic Sweat Rate Test for Cystic Fibrosis (JHU ref. 3406) This procedure describes a macroscopic cAMP-stimulated "sweat rate" test that will discriminate between ... More...   High Frequency Retrotransposition in Cultured Mammalian Cells (JHU ref. 3194) Two human L1 elements can actively retrotranspose in cultured mammalian cells. When stably expressed ... More...   A Test for the Diagnosis of Polycythemia Vera (JHU ref. 3144) Polycythemia vera (PV) is a stem cell disorder characterized as a panhyperplastic, malignant, and neoplastic ... More...   Novel Peptide Modulators for NMDA Glutamate Receptor (JHU ref. 3097) The invention concerns the identification of a novel ligand binding site on a mammalian NMDA receptor. ... More...   Platelet Polymorphism PI-A2 (JHU ref. 3034) A method for diagnosing a subject having or at risk of having a thrombotic disease syndrome is provided ... More...   Mono-Allelic Mutation Analysis  (JHU ref. 9989) Dissection of germline mutations in a sensitive and specific manner presents a continuing challenge. ... More...   A Novel Mutation Involved in Obesity and Type II Diabetes (JHU ref. 9955) A mutation has been found in the Beta3-adrenergic receptor gene, which is associated with obesity and ... More...   Staph-Enterotoxin B Receptor (JHU ref. 9883) We have discovered that a glycoshphingolipid ,digalactosylceramide serves as a receptor for SEB.And ... More...   PKD-1 (JHU ref. 9763) Autosomal dominant polycystic kidney disease is one of the most common inherited disorders of man, affecting ... More...   A Novel Molecular Analysis for Histopathology  (JHU ref. 9767) The present invention arose from the unexpected finding that nucleic acid having a mutant nucleotide ... More...   Primary Culture of Olfactory Neurons (JHU ref. 9388) The instant primary cultures of purified olfactory neurons can be stimulated with physiological levels ... More...   Cloned for the Borna DV (JHU ref. 9329) Borna disease is a sporadic fatal encephalitis which occurs in horses and sheep in Central Europe. The ... More...   CF Mutations in the CFTR Gene (JHU ref. 9328) Mutations were found in the cystic fibrosis conductance regulator protein (CFTR) between codons 548 ... More...   Cloned Human Topoisomerase I (JHU ref. 9107) The invention relates to cDNA molecules coding for eukaryotic topoisomerase I polypeptide. The invention ... More...   A Set of Cytomegalovirus Specific Recombinant DNA Clones of Defined Map Locations (JHU ref. 2292) Sets of overlapping DNA fragments covering the entire genome of the human cytomegalovirus. (92 DNA clones ... More...   CSF IL-6 as a Biomarker and Prognostic Marker in Inflammatory Disorders of the Nervous System (JHU ref. 5013) The present invention relates to soluble immune derangements in the cerebrospinal fluid of patients ... More...   Diagnostic screening for disorders of the ER-to-Golgi trafficking (JHU ref. 4960) This technology describes Cranio-lenticulo-sutural dysplasia (CLSD) as a novel autosomal recessive syndrome, ... 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