Biological Sciences : Research Tools and Diagnostics Imaging and Radiotherapy of Malaria Infection (JHU ref. C10607) JHU scientists have proposed a novel malaria parasite specific positron emission tomography (PET) imaging ... More...   A Method for Automated Detection of Intermediate Stage Age Related Macular Degeneration and other Retinal Abnormalities (JHU ref. C10562) Age related macular degeneration (AMD) is a medical condition of the retina that occurs with individuals ... More...   Improvement of ELISA methods to detect thioredoxin (JHU ref. C10475) Thioredoxin is an essential protein that acts as antioxidant and can be used as a general marker of ... More...   Conditional Alpha Synuclein Transgenic mice (JHU ref. C10840) Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder. A hallmark ... More...   Plasmid Expressing P. Falciparum Aldolase Isolate 3D7 (JHU ref. C10269) A cloned fragment of the coding exon for P.falciparum aldolase inserted into Novagen pet 29b vector More...   Plasmid Expressing P. Falciparum Histidine Rich Protein 2 Isolate FCR3 (JHU ref. C10270) A cloned fragment of the coding exon for P. falciparum histidine-rich protein 2 inserted into Novagen pet 3d (or 8c) vector More...   TEM1 (CD164L1/ endosialin) Knockout Mice (JHU ref. C10782) Tumor endothelial markers (TEMs) are genes that were found to be significantly up-regulated during angiogenesis ... More...   Methods and Protein Biomarkers Predictive of Toxic Exposure, Health Status and Disease (JHU ref. C05190) The present work describes a list of novel and specific biomarker targets and a novel data analysis ... More...   Isoprenoid Pathway Inhibitors and Assays (JHU Ref. C10727 & C10728) (JHU ref. C10727) BACKGROUND Isoprenoids are a large and diverse class of naturally-occurring organic chemical compounds ... More...   Improved Method of Infective Fungal Species Typing (JHU ref. C10633) Aspergillosis is a major cause of invasive mold infections in immune-compromised patients. Fungal infections ... More...   The Antisense Transcriptomes of Human Cells - ASSAGE (Asymmetric Strand Specific Analysis of Gene Expression) (JHU ref. C10567) BACKGROUND Serial analysis of gene expression (SAGE) is a method for comprehensive analysis of gene ... More...   Global Genetic Alterations Analysis & Novel Diagnostic/Therapeutic Biomarkers for Breast and Colorectal Cancer (JHU ref. C10471) BACKGROUND It is well accepted that cancer is the result of the sequential mutations of oncogenes ... More...   Novel Probe for O-GlcNAc Detection and Site Mapping (JHU ref. C10735) BACKGROUND The addition of O-linked ß-N-acetylglucosamine (O-GlcNAc) is a post-translational modification ... More...   Critical Component in Poly(ADP-ribose) (PAR)-mediated Cell Death (JHU ref. C10579) Apoptosis-inducing factor (AIF), a mitochondrial oxidoreductase, is released into the cytoplasm to induce ... More...   Leucine rich repeat kinase 2 (LRRK2)- mediated Neuronal Toxicity (JHU ref. C10581) Parkinson’s disease (PD), a common neurodegenerative movement disorder. Recent discovery of specific ... More...   Hyperactive Transposons for Transgenesis and Functional Genomics Studies in Mammals (JHU Ref. C10599, C10611, C10612) (JHU ref. C10599) BACKGROUND: Transposons are sequences of DNA that can move around the genome of a single cell in ... More...   PC12 Cell Lines of Inducible Expression of Disrupted in Schizophrenia (DISC1)  (JHU ref. C10725) Schizophrenia disorders are devastating mental illnesses that affect ~1% of the world’s population. ... More...   Monoclonal Antibody to Pfalciparum Aldolase (Hybridoma Clone 2B4. 5C9 or 2B4 6C1) (JHU ref. C10646) Malaria is severe disease and caused by a parasite called Plasmodium. According to the World Health ... More...   Polyclonal Antisera Specific for Neuropilin-1 and Polyclonal Antisera Specific for Neuropilin-2  (JHU ref. C10703) The semaphorin family contains a large number of phylogenetically conserved proteins and includes several ... More...   Monoclonal antibody to histidine rich protein 2 specific to Plasmodium falciparum (Hybridoma clone 299-2 HRPII 4A5) (JHU ref. C10644) Malaria is severe disease and caused by a parasite called Plasmodium. According to the World Health ... More...   Monoclonal antibody to histidine rich protein 2 specific to Plasmodium falciparum (Hybridoma clone 299-2 HRPII 3A4)  (JHU ref. C10645) Malaria is severe disease and caused by a parasite called Plasmodium. According to the World Health ... More...   Screening Method to Identify Effective Chemotherapy Drugs with Fewer Unwanted Side Effects (JHU ref. c05044) The goals of cancer treatment are to reduce tumor cell growth and to kill existing cancerous ... More...   PICK1 Knockout Transgenic Mouse Line (JHU ref. C10686) Schizophrenia is a chronic, severe, and disabling brain disorder that affects about 1.1 percent of the ... More...   A Targeted Knockout of Glutamate Receptor ionotropic AMPA1 (Gria1) Transgenic Mouse Line (JHU ref. C10687) Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain ... More...   A Synaptic GTPase-Activating Protein (SynGAP1) Transgenic Mouse Line (JHU ref. C10688) Mammalian neuronal development and synaptic plasticity are complex processes. Investigation ... More...   Easily Detectable Diagnostic Biomarker of Fungal Infection (JHU ref. C10606) Aspergillosis, the most common filamentous fungal infection, carries a high mortality rate due to diagnostic ... More...   Novel human embryonic pluripotent germ cell line, methods of producing and application (JHU ref. C03127) JHU scientists provide a human EG cell line and methods of producing such cells in vitro. They also ... More...   Monoclonal Antibody to GluR2-phosphoserine 880 (JHU ref. C10678) Glutamate receptors (GluR) mediate excitatory synaptic transmission in the central nervous system and ... More...   New Glaucoma Pathology Similarities to Parkinson’s Disease and Synuclein Polyclonal Antibody useful for Glaucoma Research (JHU ref. C10626) Glaucoma is a group of progressive eye diseases that are the second leading cause of blindness worldwide. ... More...   Modulating Notch Signaling Pathway to Control the Cell Fate Determination of Human Pluripotent Stem Cells (JHU ref. C10379) During embryonic development and adult life the Notch signaling pathway plays important roles in cell-fate ... More...   Reporters for Visualizing Signaling Pathways in Living Cells (JHU Ref. C10153, C10154, C10155, C10449, C10468) (JHU ref. C10155) Genetically encoded reporters based on fluorescence resonance energy transfer (FRET) have become powerful ... More...   Novel Diagnostic/ Prognostic Biomarker and Method for Rheumatoid Arthritis  (JHU ref. C04781) Current serological markers for RA diagnosis are non-specific and are influenced by comorbid conditions, ... More...   A Key Regulatory Subunit of a Pain and Noxious Heat Receptor (JHU ref. C10483) Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of noxious heat and capsaicin. ... More...   Novel Human alpha7 Nicotinic Acetylcholine Receptor Subunit Splice Variants (JHU ref. C04883) Abnormal alpha7 nicotinic acetylcholine receptor activity contributes to sensory gating and cognitive ... More...   MMSET Knock Out and Knock Down Multiple Myeloma Cells (JHU ref. C10575) Multiple myeloma (MM) is an incurable hematologic malignancy characterized by recurrent chromosomal ... More...   Selective Fluorescent Labeling of S-nitrosothiols (S-FLOS): Novel method to detect S-nitrosylated proteins  (JHU ref. C05036) Johns Hopkins University is seeking licensees for a powerful analytical and quantitative technique for ... More...   Methods to Identify S-Nitrosylated Proteins in Mammalian Brain Tissue  (JHU ref. C03734) A hallmark of neurological diseases such as ALS, Alzheimer’s or Parkinson’s disease is the accumulation ... More...   Rabbit Serum 2804: Antibodies Against Human LAP2 (JHU ref. C10520) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rabbit Serum 2805: Antibodies Against Human LAP2 (JHU ref. C10521) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rabbit Serum 2807: Antibodies Against Xenopus LAP2 (JHU ref. C10522) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rabbit Serum 2999: Antibodies Against Human Emerin (JHU ref. C10523) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rabbit Serum 4278: Antibodies Against Human MAN1 (JHU ref. C10525) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rat Serum 4279: Antibodies Against Human MAN1 (JHU ref. C10526) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rabbit Serum 5045: Antibodies Against Human BAF (JHU ref. C10527) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rabbit Serum 5688: Antibodies Against Rat Lmo7 (JHU ref. C10528) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   Rabbit Serum 5690: Antibodies Against Rat Lmo7 (JHU ref. C10529) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate ... More...   MR-visible and radiopaque microcapsules for use as embolic agents and for immunoisolation of cellular therapeutics (JHU ref. C04890) Immunoisolation of cells through microencapsulation is a means to prevent their immune destruction following ... More...   Embogel/Emboclear Therapeutic Solution – A Dissolvable Radio-Opaque Alginate-Based Biomaterial For Endovascular Delivery And Controlled Therapeutic Agent Release (JHU ref. C05004) EmboCaps consist of an alginate matrix with controllable porosity that provides a means of diffusion-controlled ... More...   JH-EsoAd1- Esophageal Cancer Cell Line (JHU ref. C10511) Esophageal adenocarcinoma currently has one of the most rapidly increasing tumor incidences in the United ... More...   DLD-Chk1 S317A Cells (JHU ref. C10496) Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, ... More...   Floating Chamber Set for Multi-Well Tissue Culture Plate  (JHU ref. C10459) Clear, precise immunohistochemistry data is reliant on the quality of immunolabeling and the structural ... More...   Facile, PCR Free Detection of DNA with Single Nucleotide Discrimination (JHU ref. C10146) Single nucleotide modifications in DNA have important affects on gene expression. This results in significant ... More...   Highly Efficient and Specific Oxidation of Nucleic Acids with Dinuclear Copper Complexes (JHU ref. C01726) The present invention is related to a novel method for splitting nucleic acids at specific points on ... More...   Dinuclear Copper Complexes Promote Selective Nucleobase Oxidation in a Sequence and Conformation-Dependent Manner (JHU ref. C01727) The present invention is related to a novel method for oxidizing or splitting nucleic acids at specific ... More...   Copper-Based Probes for Determining Nucleic Acid Structure In Vitro and In Vivo (JHU ref. C01661) The present invention is related to a novel method for splitting nucleic acids at specific points on ... More...   A Parkinson's Disease Cell Model and Therapeutic Target (JHU ref. C10486) Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by selective ... More...   Mutant DISC1 Inducible Transgenic Mouse Model of Schizophrenia (JHU ref. c10198) Transgenic mice with inducible expression of mutant human DISC1 (hDISC1) limited to forebrain regions were generated. More...   Screening Method to Predict Whether Candidate Psychotropic Drugs are Likely to Cause Weight Gain (JHU ref. C05045) Atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias, but their ... More...   A Method for Generating Constitutively Active Transmembrane Proteins (JHU ref. C03755) The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels. More...   Enzyme to Specifically Cleave Lys48-linked Polyubiquitin (JHU ref. C10072) A member of the deubiquitinating enzyme (DUB) family has been shown to associate with the ubiquitin ... More...   Plasmid pProEX-hOtu1 (JHU ref. C10453) The plasmid pProEX-hotu1 was constructed using vector pProEX and cDNA of human otubain 1. The plasmid ... More...   ATM Kinase Assay (JHU ref. C03504) The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. ... More...   Methylated CpG Island Amplification (MCA) (JHU ref. C03453) Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation ... More...   C38-Cystic Fibrosis Epithelial Cell Line (JHU ref. C04744) JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from ... More...   Oncogenic Osteomalacia-Related Gene 1: MEPE (JHU ref. C03812) This invention provides isolated polynucleotides encoding an oncogenic osteomalacia-related factor and ... More...   Phosphatonin-Related Gene: FRP - 4 (JHU ref. C03811) JHU scientists have uncovered methods for modulating phosphate homeostasis and renal phosphate transport ... More...   Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling (JHU ref. C03370) The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods ... More...   Targeted Mutagenesis of the Zebrafish Genome Through Manipulation of Helicase Activity (JHU ref. C10087) Helicase enzymes are important enzymes functioning in DNA replication, repair, recombination, and RNA ... More...   A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber (JHU ref. C10152) Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. ... More...   Fluorine Reporter Groups Easily Attach to Biomolecules for MR Imaging (JHU ref. C09178) JHU scientist have develeped biological compounds derivatized so as to contain at least one perfluoro-t-butyl ... More...   J HIN, J RASSF1A, J TWIST, J HIC Plasmids (JHU ref. C10434) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfate treatment. ... More...   Transgenic cell line for Flag-tagged Hypoxia-induced mitogenic factor (flag-HIMF-293) (JHU ref. C05157) Hypoxia-induced mitogenic factor (HIMF) is highly up regulated in the lungs as a result of hypoxia-induced ... More...   A Drosophila Model for LRRK-Linked Parkinsonism (JHU ref. C10263) Mutations in the leucine rich repeat kinase (LRRK2) gene causes late onset autosomal dominant Parkinson's ... More...   Method of Synthesis of Chemospheres and Chemogel, Hydrogel Embolic Particles and Gel for Locoregional Delivery of Therapeutic Agents and Immunoisolation of Cellular Therapeutics (JHU ref. C10201) JHU scientists have developed a method of producing innovative biocompatible compositions useful for ... More...   Technique for Identifying and Measuring Narp in Plasma (JHU ref. C10243) Narp is co-released with the hormone vasopressin, a hormone released in response to a number of physiological ... More...   Improved Method of Embryoid Body Formation from Human Embryonic Stem cells  (JHU ref. C10406) JHU scientists have developed an optimized method for culturing and differentiating human embryonic ... More...   Genome-wide Direct Transcription Measurement using Array-based Assay of Labeled Nascent RNA  (JHU ref. C10212) JHU scientists have developed, optimized and validated an innovative approach for study of nascent RNA ... More...   LIST-MODE IMAGE RECONSTRUCTION SOFTWARE FOR PET IMAGING (JHU ref. C10018) The technology is software capable of performing accurate and efficient reconstruction of a high resolution ... More...   A new method for co-registering PET and CT images acquired in separate dedicated small animal scanners (JHU ref. C10272) This invention is a new method to co-register PET (Positron Emission Tomography) and CT (X-Ray Computed ... More...   Novel Chimeric Transmembrane Proteins with Non-mammalian Cell Surface Domains (JHU ref. C10142) JHU scientists have generated novel human type II transmembrane based proteins that are designed for ... More...   Novel Target for Huntington’s Disease and Therapeutic Agent Screen (JHU ref. C10420) Huntington's disease (HD) is a progressive neurodegenerative disease that causes both mental and physical ... More...   Zebrafish and Mouse Sox10 Transgenic Reporter Lines That Mark Neural Crest and Oligodendroglial Populations (JHU ref. c10416) Sox10 is a dynamically regulated transcription factor gene that is essential for the development of ... More...   N-ethylmaleimide sensitive factor (NSF) Antibody (JHU ref. C03959) N-ethylmaleimide sensitive factor (NSF) is as an ATPase that modulates vesicular transport and influences ... More...   Mouse Monoclonal Antibody 8A2 (JHU ref. C10322) This technology is a mouse monoclonal antibody, which specifically recognizes vertebra SUMO-2 and SUMO-3. ... More...   Real-time, Non-invasive Imaging Method for Mycobacterium Tuberculosis Infection (JHU ref. C10401) Tuberculosis (TB) is one of the leading infectious causes of morbidity and mortality worldwide. Experts ... More...   Multiple Novel Hormone Receptor Variants as Biomarkers and Therapeutic Targets for Hormone Independent Human Prostate Cancer (JHU ref. C10305) Prostate cancer is a prevalent disease in aging males and is sensitive to androgen deprivation, the ... More...   The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle Cell (JHU ref. C10362) Isolation of primary cell populations is complex and requires a significant amount of technical expertise ... More...   Mouse Monoclonal Antibody 8A2 (JHU ref. C10322 ) This technology is a mouse monoclonal antibody, which specifically recognizes vertebra SUMO-2 and SUMO-3. ... More...   Cell Line 2V6.11 (JHU ref. C10340) The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), in concert with the 55 kDa product of E1b, ... More...   Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data SNPtrio (JHU ref. C10342) Chromosomal DNA alterations can be detected using high density single nucleotide polymorphism (SNP) ... More...   Three Software Tools for Analysis of Chromosomal Abnormalities in High Density Genomic Data (JHU ref. C10343) High density single nucleotide polymorphism (SNP) data have been used to identify chromosomal changes ... More...   Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data. (JHU ref. C10344) The SNP software analysis tools use a novel "reverse pedigree" method to detect genetic differences ... More...   ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC1 M1, and HIC1 U3 plasmids (JHU ref. C10165) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment. More...   MKK4/MAP2K4 KO Lines for Drug Discovery (JHU ref. C10131) MKK4 (JNKK1, MAP2K4, and SEK1), a dual-specificity kinase gene on chromosome 17p11, is a tumor suppressor ... More...   PET32a O-GlcNAcase-thioredoxin Expression Vector (JHU ref. C10105) Expression and Purification of Recombinant and Endgenous 0- GlcNAcase The human O-GlcNAcase cDNA was ... More...   Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity (JHU ref. C10100) A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing ... More...   Cell Lines with Targeted Deletions of p53 (JHU ref. C10083) Cell lines with deletions of p53 can be used for testing the specificity of drugs that target the p53 ... More...   Seventy Two Gene Model for 8 Thyroid Tumor Types (JHU ref. C10073) Thyroid cancer represents 90% of all neuroendocrine malignancies with an estimated annual incidence ... More...   Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7 (JHU ref. C10075) Chromosomal instability, the continuous formation of novel chromosome mutations at a rate higher than ... More...   Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA (JHU ref. C10034) It is generally agreed that internal human xenografts provide the best animal models to study the microenvironments ... More...   Multivariate Statistical Modeling Biomarkers as Predictors of Recurrence Following Radical Prostatectomy (JHU ref. C09828) A method for screening individuals at risk for prostate cancer progression is disclosed. The method ... More...   BRCA2 KO Lines for Drug Discovery (JHU ref. C05188) BRACA2 is a DNA repair gene. Mutations in BRACA2 cause an inherited risk of breast, ovarian and pancreatic ... More...   Diagnostic; Therapeutic; Screening of Drugs/Agents; Herpes Simplex Virus I; Epstein Barr Virus; Infectious Diseases/Agents; Cancer/Carcinogenesis (JHU ref. C05155) Gastrin and the cholecystokinin type B/gastrin receptor (CCKBR) have been shown to be expressed in colorectal ... More...   High throughput generation of water-in-oil emulsions for molecular genetic analyses (JHU ref. C05006) Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), ... More...   O/E2 and O/E3 Knockout Mice (JHU ref. C04602) The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been ... More...   Neovascular and (alpha)(nu)(beta)3/5 Retargeted Adenovirus Delivering Interleukin-12 (JHU ref. C04534) This invention employs an engineered retargeted adenoviral vector to locally deliver genes with immunologically ... More...   JSC1 (JHU ref. C04349) This primary effusion lymphoma (PEL) cell line was established from lymphomatous peritoneal effusion ... More...   Antibody to Human DNA Methyltransferase 1 (JHU ref. C04328) We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human ... More...   A Photoreceptor Cell-Specific ATP Binding Transporter Gene (ABCR) is Mutated in Recessive Stargardt Macular Dystrophy (JHU ref. C03195) Vitelliform macular dystrophy (VMD/Best disease) is an early-onset autosomal dominant disorder in which ... More...   Novel Genes of Kaposi's Sarcoma Associated Herpesvirus (Human Herpesvirus Eight) (JHU ref. C03120) Karposi sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is a virus commonly occurring ... More...   Method for High Throughput Thermodynamic Screening of Ligands (JHU ref. C01507) The optimization of lead compounds as viable drug candidates involves the optimization of their binding ... More...   Generation of Leucine Rich Repeat Kinase-2 (LRRK2) Knockout Mice (JHU ref. C10385) Mutations in Leucine repeat rich kinase 2 (LRRK2) are associated with familial Parkinson’s disease. ... More...   Generation of Leucine-rich Repeat Kinase 2 (LRRK2) Wild-type and mutant LRRK2 Transgenic Mice (JHU ref. C10386) Mutations in the Leucine-rich Repeat Kinase 2 (LRRK2) gene are a common cause of late-onset familial ... More...   Imaging Methods for Assessment and Quantification of in vivo Antigen Capture and Vaccination (JHU ref. C10228) Immunization has eradicated many harmful infectious diseases in the Western world. This is commonly ... More...   Mouse Model of Human Head and Neck Squamous Cell Carcinoma (JHU ref. 10173) Cancers of the head and neck, the majority of which arise in the squamous cells that line the mucosal ... More...   A Biotin-labeled Antibody for the Pre-clinical Diagnosis of Alzheimer’s Disease (JHU ref. c10046) Amyloid beta (Aß) is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. ... More...   A New Molecular Target for Cancer Therapy  (JHU ref. C10116) Many human cancers are refractory to conventional therapeutic approaches. Therefore, identification ... More...   Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity (JHU ref. 10100) A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing ... More...   S9 Cystic Fibrosis Cell Line (JHU ref. 4772) Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. ... More...   Site-specific Modification of the Human Genome Using Custom-designed ZFNs (JHU ref. 4775) Scientists at JHU have designed sets of Zinc Finger Nucleases (ZFN) to target mouse genes, namely the ... More...   Discovery of novel HTLV-3 and HTLV-4 retroviruses (JHU ref. 5001) Scientists at JHU have recently discovered the existence of two new types of Human T Lymphotropic Viruses ... More...   Mutational analysis of the tyrosine phosphatome in colorectal cancers (JHU ref. 4435) JHU researchers have performed a comprehensive mutational analysis of the protein tyrosine phosphatases ... More...   Floxed Ret Mouse (JHU ref. 10009) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation ... More...   Novel Targets for Control of M. Tuberculosis Growth (JHU ref. C10086) Tuberculosis infection kills roughly two million people per year and a third of the world population ... More...   Enzyme to specifically cleave Lys-48 linked polyubiquitin (JHU ref. 10072) A member of the deubiquitinating enzyme (DUB) family has been shown to associate with the ubiquitin ... More...   Methods and Use of Labeling Cells with X-ray and Ultrasound-Visible Agents (JHU ref. 10065) Cell tracking has found major applications in immune and stem cell therapy. This is commonly done with ... More...   Estrogen Receptor in Normal (ERIN) cells (JHU ref. 4908) There is no ideal system for studying pre-neoplastic cells that are ERa positive due to the inability ... More...   PXA1, PXA2, PXA3, PXA4, PXA5, PXA6 Cell Lines (JHU ref. 4411) The invention consists of low-passage cell lines generated from primary pancreatic cancers established ... More...   Formation of Functional Motor units and Recovery from Paralysis Using Embryonic Stem Cell Transplantation. (JHU ref. 4995) The technology describes the potential of embryonic stem cell-derived motor neurons to functionally ... More...   Vac-N (Vaccinia encoding SARS-CoV N protein) (JHU ref. 4561) Vac-N (Vaccinia encoding SARS-CoV N protein) More...   Diagnostic Assays For a Polymorphism in a Gene That Affects Cardiovascular Health (JHU ref. 5125) High density lipoproteins (HDL) are considered good or healthy cholesterol that can protect against ... More...   Human cell line expressing Flag-tagged Hypoxia-induced mitogenic factor (HIMF). (JHU ref. 5157) Hypoxia-induced mitogenic factor (HIMF) is highly up regulated in the lungs as a result of hypoxia-induced ... More...   Biomarkers Differentially Expressed in Ovarian Cancer Cells with Deactivation of the MAPK Pathway (JHU ref. 10045) Activation of the MAPK signaling pathway has been implicated in many human cancers. Scientists at JHU ... More...   Selective, Facile, Quantitative Detection Method for 2'-deoxyguanosine intermediates (JHU ref. 10027) A variety of structural modifications (lesions) are produced in DNA when the biopolymer is exposed to ... More...   Selective, Facile, Quantitative Detection of Oxidized Abasic Lesions in DNA (JHU ref. 10026) A variety of structural modifications (lesions) are produced in DNA when the biopolymer is exposed to ... More...   Cartilage Fluorescent Reporter Transgenic Zebrafish  (JHU ref. 10020) In mammalian model organisms, cartilage formation and maturation is visually inaccessible, whether in ... More...   Bioreactor (Cartridge) for in vitro pharmacokinetic/pharmacodynamic system (JHU ref. 10015) JHU scientists have developed a special bioreactor (cartridge) that permits growth of protozoan parasites ... More...   Method for imaging cannabinoid receptor type 1 (CB1) using radiolabeled 4-cyano-1,5-diphenyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamides  (JHU ref. 5025) Radioligand development for Positron emission tomography imaging of the cerebral cannabinoid receptor ... More...   PIK3CA exon 9 and exon 20 Knock in Cells (JHU ref. 10035) PIK3CA exon 9 and exon 20 knock in cells within the MCF-10A human breast epithelial cell line. More...   Estrogen Receptor in Knock out (ERIK) cells (JHU ref. 10036) Receptor positive non-tumorigenic human breast epithelial cell line derived from the commercially available ... More...   K-Ras Knock in human breast non-tumorigenic breast epithelial cells  (JHU ref. 10037) Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available ... More...   IB3-1 Cystic Fibrosis Cell Line (JHU ref. 4681) Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. Cells were immortalized with adeno12SV0. More...   BRCA2 KO Lines for Drug Discovery (JHU ref. 5188) BRACA2 is a DNA repair gene. Mutations in BRACA2 cause an inherited risk of breast, ovarian and pancreatic ... More...   Alkenal/one Oxidreductase (AOR) cDNA and protein (JHU ref. 4394) Alkylating agents are useful compounds as anticancer drugs as they possess electrophilic characteristics ... More...   Peroxipen: Western Blot Marker (JHU ref. 10024) Western blotting is a very common and powerful technique employed by molecular biologists and other ... More...   Floxed GFRalpha-1 Mouse (JHU ref. 10008) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation ... More...   New Method of Collecting Exhaled Breath Biomarkers at Room Temperature (JHU ref. 10003) A simple method of collecting biomarkers that is fast, simple, and accurate is important for both research ... More...   Automated, inexpensive, liquid delivery device for the robust, reproducible, efficient, multiplexed and gentle processing of affinity matrices (JHU ref. 5187) Scientists at JHU have developed an inexpensive device for the automated delivery of unlimited solvent ... More...   Serum Response Factor (SRF) Conditional Knockout Mice (JHU ref. 5168) Scientists at JHU have created conditional serum response factor (srf) knockout mice to investigate ... More...   The Transcriptome Interaction Database (TID): A Novel Bioinformatic Method and Software Package for Analysis of MicroRNA-mRNA Interactions and Their Consequences (JHU ref. 5117) Researchers at JHU have developed the Transcriptome Interaction Database (TID), a centralized relational ... More...   MicroRNA Expression and Control of Stem Cell Pluripotency, Differentiation and Cellular Processes (JHU ref. 5118) MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind to the 3' untranslated region of mRNAs ... More...   Near infrared fluorescent 6-O-glucosamine compounds with targeting specificity to lysosomes in tumors  (JHU ref. 5019) Optical imaging is a non-invasive, diagnostic imaging technology which can be used to inexpensively ... More...   A novel antibody to platelet endothelial cell adhesion molecule-l (JHU ref. 5134) PECAM-l (CD 31), a member of the IG superfamily, is expressed strongly at endothelial cell junctions, ... More...   Biofunctional Fibers (JHU ref. C05138) The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization ... More...   Controlled Microencapsulation of Mammalian Cells (JHU ref. C05121) The present invention is directed to an automated device and method to prepare polyelectrolyte microcapsules ... More...   Pdk1 Cleavage –Deficient Mouse (JHU ref. 5097) Scientists at JHU have created a novel mouse model of polycystic kidney disease (PKD), one of the most ... More...   Sensitive Assay to Detect HIV neurotoxic proteins and Antibodies in Spinal Fluid  (JHU ref. C05087) Johns Hopkins University is currently seeking licensees for an innovative method to detect toxic HIV ... More...   Histone Mutant Plasmid Collections (JHU ref. 5076) Epigenetics, the study of stable alterations in gene expression that arise during development and cell ... More...   Rapid predictive assay for malignancies treated with polo-like kinase-1 (PLK1) inhibitors and cell cycle modulators (JHU ref. 5065) Scientists at JHU have developed a pharmacodiagnostic assay for patients treated with targeted therapies ... More...   Tamoxifen-resistant MCF-7 Breast Cancer Cell Line (JHU ref. 5047) MCF-7 cells serve as a prototypic model system for human breast cancer and their response to secretive ... More...   Identification of Staphylococcal Enterotoxin-B (SEB) Sequences Involved in Cell Proliferation and Cell Death (JHU ref. C05048) Studies suggest that staphylococcal enterotoxin B (SEB) is initially harbored in the kidney by binding ... More...   Monoclonal antibodies (mAB) specifically against mouse and human LIGHT and B7-H4 molecules (JHU ref. 5037) Scientists at JHU have made monoclonal antibodies against mouse and human LIGHT and B7-H4 molecules. More...   Huntington's Disease (HD) Mouse Model, N171-82Q. (JHU ref. 5027) This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines ... More...   Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant  (JHU ref. 5018) Human telomerase reverse transcriptase (hTERT) is activated in thyroid cancer. Despite this, its usefulness ... More...   ATR-Seckel Cancer Cells for Drug Discovery (JHU ref. 4993) Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal ... More...   High efficiency human gene targeting with recombinant AAV and a synthetic exon promoter trap (SEPT) (JHU ref. 4990) Gene targeting via homologous recombination is a powerful means of assessing gene function in many organisms, ... More...   Development of Peptide Antibody Depletion (PAD) and its Application to Mass Spectrometry Sample Preparation (JHU ref. C04975) One of the major limitations of mass spectrometry is obtaining mass information on proteins in the presence ... More...   A Novel HPV Detection Method on Oral Cytology Samples for Diagnosis and Screening for Oral Cancer (JHU ref. 4940) Each year in the United States there are approximately 17 per 100,000 new diagnoses for head and neck ... More...   The novel effects of NAD-related compounds (nicotinamide, nicotinamide mononucleotide, and NAD) on blood glucose levels.  (JHU ref. 4965) Scientists at JHU have discovered of a novel blood-circulating form of Nampt. This novel isoform a slightly ... More...   A Screening Assay for the Identification of Functional Defects in the Proximal Fanconi Anemia Pathway (JHU ref. 4962) Inactivation of Fanconi Anemia (FA) genes occurs in a variety of tumors among the general population ... More...   TC-1/A2 – Anti-tumor mouse model (JHU ref. 4953) Scientists at JHU have developed an HLA-A2 expressing tumor mouse model that can naturally process and present E7 antigen via HLA-A2 molecules. More...   A Method of Screening a Compound which Induces CPT-1C Expression or Functionally Activates CPT-1C for the Treatment of Obesity and/or Diabetes.  (JHU ref. 4959) Fatty acid synthesis in the central nervous system has been implicated in the control of food intake ... More...   A rapid assay using Fine Needle Aspiration (FNA) to test for 5-fluorouracil dosing and efficacy (JHU ref. 4947) Scientists at JHU have developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil ... More...   Multiple Inversion Flip Flop (MIFF) Vectors. (JHU ref. 4945) JHU researchers have developed novel Multiple Inversion Flip Flop (MIFF) plasmid vectors for controlling ... More...   SIV Molecular Clones: SIV/17E-Fr, SIV/17E-C1, SIV/3-11RG, and SIV/3-7  (JHU ref. 4943) JHU researchers have constructed infectious simian immunodeficiency virus (SIV) molecular clones that ... More...   xKLuSIV Cells: Human Cell Lines That Express SIV/HIV Receptors And Co-Receptors. (JHU ref. 4924) Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors, with or without ... More...   MEK KO Lines for Drug Discovery (JHU ref. 4918) MEK knockout in human colorectal cancer cell line HCT116 More...   PKHD1 FLOX3-4 mouse cell line as a model for obesity (JHU ref. 4916) Pkhd1flox3-4, when mutated, causes human autosomal recessive polycystic kidney disease (ARPKD). The ... More...   MR-visible and Radiopaque Microcapsules (JHU ref. 4890) Immunoisolation of cells through microencapsulation is a means to prevent their immune destruction following ... More...   A. phagocytophilum Monoclonal Antibody hybridomas (JHU ref. 4888) Researchers at JHU have created hybridomas producing monoclonal antibodies reactive with the obligate ... More...   Identification of the Most Common Gene for Bardet-Biedl Syndrome (JHU ref. 4887) Bardet-Biedl syndrome (BBS) is characterized by multiple clinical phenotypes including retinal dystrophy, ... More...   Increasing the Depth and Breadth of Coverage of Sequences on a Microarray (JHU ref. 4884) Microarrays are used as an investigative tool for answering questions concerning DNA sequence and structure, ... More...   Co-assembling Peptide Hydrogels (JHU ref. 4880) Peptide-based hydrogels have become popular for biomedical applications such as tissue engineering and ... More...   A high-throughput screening method for the identification and validation of T-cell epitopes (JHU ref. 4875) All currently established methods for the identification of immunogenic epitopes are extremely tedious, ... More...   Fanconi Anemia Gene KO Cell Lines for the Identification of Compounds with DNA-interstrand Cross linking Capability (JHU ref. 4868) Using somatic cell gene targeting, isogenic cell clones were created from the colorectal cancer cell ... More...   COMPARE-MS: A Novel Technique for Rapid, Sensitive, and Accurate Detection of DNA Methylation  (JHU ref. 4871) Hypermethylation of CpG island (CGI) sequences is a nearly universal somatic genome alteration in cancer. ... More...   Prostate Specific Membrane (PSMA)-binding Peptides Useful for Targeted Therapy for Cancer (JHU ref. 4856) Prostate-Specific Membrane Antigen (PSMA) is a glutamate carboxypeptidase II that is expressed by normal ... More...   Emission Ratiometric Kinase Reporters (JHU ref. 4851) Protein phosphorylation is one of the major regulatory mechanisms controlling cellular functions and ... More...   Emission Ratiometric cAMP Reporters (JHU ref. 4509) The classic second messenger, cAMP, coordinates many cellular functions via its effectors such as Epac ... More...   Cost effective method for preparing the chelating agent DOTA-tris-(t-Bu) ester. (JHU ref. 4842) l-(acetic acid)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10 tetraazacyclododecane (synonym DOTA-tris-(t-Bu) ... More...   Identification of Cancer Drug Targets as Common Nodes in Genetic Interaction Maps (JHU ref. 4826) A major goal in biology is to identify all genes whose function contributes to the maintenance of genome ... More...   A new method to increase memory T lymphocytes using a monoclonal antibody (JHU ref. 4819) CD137 has long been recognized as a co-stimulatory receptor for growth and functional maturation of ... More...   A Method for the Efficient Functional Examination of Mammalian Noncoding Sequences in Transgenic Zebrafish (JHU ref. 4815) Evolutionary sequence conservation is recognized as a reliable indicator of both coding and non-coding ... More...   pT2cfosGW vector (JHU ref. 4814) A current hypothesis is that sequences conserved over greater evolutionary distances are more likely ... More...   p21 Knock Out Human Mammary Epithelial Cell Lines (JHU ref. 4193) MCF-I0A human breast epithelial cell lines devoid of the p21 gene. More...   Arginase, A Target Enzyme for the Treatment of Myocardial Dysfunction in Aging and Heart Failure (JHU ref. 4729) This invention comprises a novel method to treat heart failure and age-related myocardial dysfunction ... More...   Novel Imaging Agent to Detect Multidrug Resistance in Tumors Using Multimodality Imaging (JHU ref. 4776) Multidrug resistance (MDR) can develop during chemotherapy to desensitize tumors to a variety of structurally ... More...   Genomic and Protein Biomarkers for Cystic Fibrosis. (JHU ref. 4777) Cystic fibrosis is a common lethal genetic disease which is manifest by intrinsic hyperactivation of ... More...   Molecular Targets for the Anti-cancer Natural Product Pateamine A and its novel synthetic derivatives (JHU ref. 4774) The natural marine product Pateamine A (PatA) is a potent anti-tumor and pro-apoptotic agent. Until ... More...   Uracil-Directed Ligand Tethering: An Efficient Strategy for Small Molecule Inhibitor Development Against Human Uracil DNA Glycosylase and Other Enzymes the Recognize Uracil (JHU ref. 4765) The nuclear form of human uracil DNA glycosylase (hUDG) is a protein that is required for the infection ... More...   Yeast Knockout Mutation (YKO) Collections and Yeast Double Knockout Collections (JHU ref. 4228) JHU researchers have produced collections of single and double yeast knockout (YKO) mutants. More...   Microarray Gene Expression Profiling of IBD Endoscopic Biopsy Tissues and Identification of Biomarkers (JHU ref. 4543) This invention relates to the identification of biomarkers for ulcerative colitis (UC) and Crohn's disease ... More...   Methods of Non-Biological Combinatorial Library Construction and Replication. (JHU ref. 4589) This invention relates to a method of producing combinatorial libraries from non-biological molecules ... More...   p16 KO Lines for Drug Discovery (JHU ref. 4650) p16 tumor suppressor gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are ... More...   SMAC KO Lines for Drug Discovery (JHU ref. 4651) Second mitochondrial-derived activator of caspase (SMAC; also known as Diablo) gene knockouts of the ... More...   Dicer KO Lines for Drug Discovery (JHU ref. 4653) Dicer RNase gene knockouts in human cell lines. More...   RAF KO Lines for Drug Discovery (JHU ref. 4654) BRAF kinase gene knockouts of human cancer cell lines. More...   CHK2 KO Lines for Drug Discovery (JHU ref. 4655) Chk2 protein kinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are ... More...   DEC1 KO Lines for Drug Discovery (JHU ref. 4656) Deleted in esophageal cancer 1 (DEC1) gene knockouts of the human keratinocyte cell line, HaCaT. Details ... More...   XIAP KO Lines for Drug Discovery (JHU ref. 4657) X-linked inhibitor of apoptosis protein (XIAP) gene knockouts of human colon cancer cell lines. Details ... More...   HAUSP KO Lines for Drug Discovery (JHU ref. 4658) HAUSP (also known as USP7) deubiquitinase gene knockouts of the human colorectal carcinoma cell line, ... More...   Fluorescent 6’-O-glucosamine compounds to label lysosomes in tumors in vivo and in cell culture systems for detection with optical imaging or fluorescence microscopy (JHU ref. 4739) Lysosomes contain numerous proteases, the release of which may play a vital role in breast cancer invasion ... More...   A Tissue Assay for the Effectiveness of the Anticancer Drug 5-Fluorouracil and Related Compounds (5FU) (JHU ref. 4778) A functional assay has been developed for a class of widely used anti-cancer drugs, 5-fluorouracil and ... More...   RAS KO Lines for Drug Discovery (JHU ref. 4733) RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 (see below). More...   New Class of Reporter Genes for MRI Based on Chemical Exchange Saturation Transfer (CEST) (JHU ref. 4616) Among the clinically applied 3D imaging modalities, magnetic resonance (MR) imaging has the highest ... More...   Emission Ratiometric Reporter for Phosphoinositides (JHU ref. 4722) The phosphatidylinositols PIP(3,4)2 and PIP3 are important secondary messengers that regulate a variety ... More...   Olfactory Receptor I7 Targeted O/E3 Knockout Mice. (JHU ref. 4716) The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been ... More...   Hypoxia-induced Mitogenic Factor (HIMF) As a Treatment for Acute Lung Injury (JHU ref. 4711) Lipopolysaccharide (LPS) is a component of the outer membrane of gram-negative bacteria that induces ... More...   Instrument System for Managing and Cherry Picking Microorganism Collections (JHU ref. 4707) Large biomaterial collections require precise and selective access to a subset of material under sterile ... More...   Hi-Throughput Assay for Screening Small Molecule Inhibitors of Uracil DNA Glycosylase (JHU ref. 4701) Uracil DNA glycosylase (UDG) is one of the primary enzymes that prevents the incorporation and accumulation ... More...   Methods for identifying mutations in coding and non-coding DNA (JHU ref. 4692) Annotation of the completed human genome has demonstrated that about 1.5 % encodes protein. About twice ... More...   Role of the RET+9.7 Enhancer Mutation in Hirschsprung Disease (JHU ref. 4693) Hirschsprung disease (HSCR) occurs in 1/5000 live births. While the complex pattern of HSCR inheritance ... More...   Shh Light2 Cells (JHU ref. 4409) Cell line derived from the NIH/3T3 cell line transfected with GLI-responsive Firefly luciferase reporter ... More...   Genes Overexpressed in Pancreatic Cancer Identified Through the Biocomputational Analysis of ESTs (JHU ref. 4443) JHU researchers have identified a number of genes highly overexpressed in pancreatic adenocarcinoma. ... More...   HMG-1 transgenic mouse (JHU ref. 4452) The HMG-I/Y gene is overexpressed in human cancer, although a direct role for this gene in transformation ... More...   Genes Overexpressed in Pancreatic Cancer as Identified by a Re-examination of the SAGE Database (JHU ref. 4526) JHU researchers have identified a number of genes highly overexpressed in pancreatic cancer compared ... More...   Generation of Isogenic Lines Differing Only in MLH1 Status (JHU ref. 4626) JHU researchers have created matched cell lines which are isogenic, differing only in the MLH1 alleles. ... More...   MTAP KO Lines for Drug Discovery (JHU ref. 4647) Methylthioadenosine phosphorylase (MTAP) plays an important role in the salvage pathway for the synthesis ... More...   PTEN KO Lines for Drug Discovery (JHU ref. 4648) PTEN is a tumor suppressor gene that is frequently mutated or deleted in a variety of human cancers ... More...   Growth of mesenchymal stem cells under non adherent conditions for clinical applications (JHU ref. 4683) The use of bone marrow derived mesenchymal stem cells (MSC) has been proposed for a number of regenerative ... More...   A Novel PGC-1alpha/SIRT1 Deacetylase Interaction (JHU ref. 4471) Homeostatic mechanisms in mammals respond to hormones and nutrients to maintain blood glucose levels ... More...   Therapeutic Target for Both Cancer and Ischemic Diseases  (JHU ref. 4536) This invention addresses two desired outcomes relating to cells exposed to ischemic or low oxygen tension ... More...   A method for high-efficiency clonal isolation and expansion of human embryonic stem cells (JHU ref. 4575) JHU researchers have developed a method and identified growth factors for high efficiency cloning, clonal ... More...   O/E2 and O/E3 Knockout Mice (JHU ref. 4602) The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been ... More...   PIK3CA KO Lines for Drug Discovery (JHU ref. 4652) PIK3CA knockouts in human colorectal cancer cell lines HCT116 and DLD1. Details are described in the paper by Samuels et al., 2005 (see below). More...   High frequency retrotransposition of synthetic retrotransposons in vivo  (JHU ref. 4645) JHU scientists in collaboration with the University of Pennsylvania, have reported the successful construction ... More...   Method and device for identifying terrorists/criminal suspects by detecting contact of human skin with rubber protective gear (JHU ref. 4362) Dithiocarbamates (DTC) are widely used in the vulcanization of natural and synthetic rubber protective ... More...   Digital HLA Typing (JHU ref. 4453) JHU researchers have developed a cost effective, high resolution, high throughput method for determination ... More...   BACE2 Knockout Mice (JHU ref. 4556) Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta ... More...   Facile Modification of Collagen Directed by Synthetic Peptides (JHU ref. 4571) Currently, there is significant biomedical interest in modifying natural collagen to improve its biochemical ... More...   Reagents for the selective Detection of the C1'-oxidized Abasic Site (2-deoxyribonolactone) in DNA (JHU ref. 4596) JHU researchers have developed a novel method for selectively detecting 2-deoxyribonolactone, a commonly ... More...   The Amino Acid Noose of the Attachment Protein of Respiratory Syncytial Virus (RSV) Inhibits the Effects of the Endotoxin and the Innate Immune Response (JHU ref. 4477) Both endotoxin and RSV protein F stimulate CD14/TLR4 receptor in monocyte/macrophages resulting in a ... More...   Selective Dorsal Rhizotomy of Pain Signaling Nerve Fibers (JHU ref. 4516) JHU researchers have invented a technique that allows selective blockade of the neuronal input of nociceptive ... More...   Transgenic Frog Lines to Study Retina Degeneration (JHU ref. 4517) A JHU researcher has developed lines of transgenic frogs in which transgenes induce photoreceptor degeneration ... More...   A Novel Genetic Approach to inhibit or Eliminate the Tumorgenicity of Human Embryonic Stem Cells and/or their Derivatives After Transplantation. (JHU ref. 4622) Pluripotent embryonic stem cells have enormous potential for providing an unlimited supply of multipotent ... More...   Test for Colon Cancer Adenoma Formation Risk and Possibly Risk of Other Tumor Type Formation (JHU ref. 4482) This invention provides a strategy for identifying patients at risk of colorectal cancer, and likely ... More...   Unexpected Cross-neutralization of Cutaneous & Mucosal Papillomavirus Types with Anti-Sera to a Novel Epitopes  (JHU ref. 4603) High risk Human Papillomavirus (HPV) infection is a common cause of cervical cancer. Researchers at ... More...   Structural Prediction of Allosterism  (JHU ref. 1539) During the course of biological function, proteins interact with other proteins, ligands, substrates, ... More...   Method of Detection of Anal Neoplasia (JHU ref. 4519) Each year in the United States there are approximately 3400 new cases of carcinoma of the anal canal. ... More...   Transgenic Mouse Line Expressing Wild-Type Human Amyloid Precursor Protein (APP). (JHU ref. 4586) Researchers at Johns Hopkins and Case Western Reserve University have generated a transgenic mouse (Py8.9) ... More...   Monitoring Functional Kinetics of Vesicular Trafficking (JHU ref. 4462) The present inventive method is designed to measure the rate of protein trafficking to cell surface. ... More...   Myocyte Enhancer Factor 2 (MEF2) Mediates Calcium-Dependent Transcription of the Interleukin-2 Gene in T Lymphocytes (JHU ref. 4386) MEF2 is a transcription factor that is known to play a role in muscle differentiation and thymocyte ... More...   Method and Kit for Diagnosis and Drug Screening Towards Psychiatric Disorders  (JHU ref. 4397) This invention relates to a method and kit for diagnosis and drug screening towards psychiatric disorders. ... More...   Mutations of the PIK3CA Gene in Human Cancers  (JHU ref. 4407) Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important ... More...   Hypomorphic Mouse Mutant of PASG, an SNF2L Factor, That Leads to Growth Retardation and Premature Aging (JHU ref. 4428) Researchers at JHU have shown that PASG (Proliferation Associated SNF2-Like gene, also termed lsh or ... More...   PACE 4 Antisera and Cells (JHU ref. 4499) Rabbit antibodies against the proprotein processing enzyme PACE4; cell lines stably secreting PACE4 More...   Identification of a Binding Partner for the Endothelial Cell Surface Proteins (JHU ref. 4513) Targeting the endothelial cells that line tumor blood vessels is a promising new strategy for the treatment ... More...   Forward Trafficking Motifs and their Uses  (JHU ref. 4367) The inability to express a membrane receptor on a cell-surface represents one of the most common and ... More...   Hedgehog Pathway Antagonists (JHU ref. JHU Ref. 4341) The Hedgehog pathway is known for its important role in inductive interactions that regulate growth ... More...   Wnt Pathway Antagonists   (JHU ref. JHU Ref. 4342) The Wnt signaling pathway is known for its important role in inductive interactions that regulate cellular ... More...   Cloning and Isolation of the Large Ribosomal Subunit Proteins from E. coli for the in vitro reconstitution of functional 50S Subunits (JHU ref. 4466) For the first time, JHU researchers have cloned, expressed and purified each of 34 individual large ... More...   A dwarf mouse with growth hormone deficiency due to targeted ablation (Knock out) of the GHRH gene. (JHU ref. 4531) The proliferation of pituitary somatotroph cells and the synthesis and secretion of GH are under the ... More...   Method for the Detection of Schistosome Parasites  (JHU ref. 4473) Schistosomes cause serious disease in humans and warm-blooded animals by living parasitically in the ... More...   Antisera to Pax-6 Protein (JHU ref. JHU Ref. 3443) A rabbit polyclonal antisera which recognizes the developmentally important protein marker, Pax-6, in ... More...   Yeast Strain S288C (JHU ref. JHU Ref. 3513) A yeast strain based on Saccharomyces cerevisiae S288C in which commonly used selectable marker genes ... More...   GDF-1 Knockout Mouse  (JHU ref. JHU Ref. 3691) Transgenic knockout mouse serves as a useful tool to identify the developmental activity associated ... More...   A Transposition System that Can Be Modified to Facilitate Cloning (JHU ref. JHU Ref. 3756) A useful research tool that provides a large number of intermolecular simple insertions of the bacterial ... More...   pNB1 + pNB3 (JHU ref. JHU Ref. 4005) These molecular biology research tools are recombinant yeast plasmids that were designed for use with an in vitro Tn7 transposition system. More...   Eight Anti-ganglioside Monoclonal Antibodies (JHU ref. JHU Ref. 4184) Monoclonal antibodies to major brain cell surface antigens involved in axon-myelin stability, nerve ... More...   PK15NTD Cells (JHU ref. JHU Ref. 4252) Cell line derived from swine kidney tubular epithelial cells which are deficient in endogenous nucleoside transporters. More...   hENT2/PK15NTD (JHU ref. JHU Ref. 4258) Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT2 as its only nucleoside transporter. More...   hENT3/PS120  (JHU ref. JHU Ref. 4259) Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT3. Human ENT3 is a golgi nucleoside transporter. More...   hENT1/PK15NTD  (JHU ref. JHU Ref. 4257) Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT1 as its only nucleoside transporter. More...   hCNT3/PK15NTD  (JHU ref. JHU Ref. 4306) Cell line derived from swine kidney tubular epithelial cells which contains transfected human CNT3 as its only nucleoside transporter. More...   4xwtCBF1-Luciferase and 4xmtCBF1-Luciferase Reporters (JHU ref. JHU Ref. 4376) 4xwtCBF1-Luc(pJH23A) is a luciferase reporter plasmid that contains 4 copies of a binding site for CBF1. ... More...   Anti-rat Melanopsin N-terminus Antibody (JHU ref. JHU Ref. 4377) Research tool that can be used for immunohistochemical labeling of melanopsin-containing ganglion cells in rodent models. More...   Immune Modulation Through Targeting of the MINOR Gene (JHU ref. JHU Ref. 4406) This invention describes the use of a novel gene to improve dendritic cell function and survival. Expression ... More...   Transgenic Mice that Express a Mutated Form of Human Superoxide Dismutase 1. (JHU ref. 4495) Mutations in superoxide dismutase 1 cause familial forms of amyotrophic lateral sclerosis (ALS). To ... More...   TH - Cre Mouse (JHU ref. JHU Ref. 4421) A transgenic mouse, which produces the Cre Recombinase in Catecholaminergic Neurons. More...   TH, Bcl Conditional KO mouse (JHU ref. JHU Ref. 4422) Transgenic mouse that lacks expression of Bcl-x in Tyrosine Hydroxylase-positive Neurons. More...   pFex: An Adenoviral Fiber Exchange Shuttle System (JHU ref. 4410) The value of re-targeted adenoviral vectors is becoming apparent in the current age of gene therapy. ... More...   Ty Transposon Plasmids  (JHU ref. 3023) These clones (pJEF1267/pJEF1262/pD123/pX6/pJEF1114) are useful tools for generating yeast strains with ... More...   W162 Cells, Adenovirus Mutants H5dl1014 and H5dl1014 (JHU ref. 3177) W162 cells are transformed Vero cells which permit highly efficient plaque formation by deletion mutant ... More...   Hybridoma H5C6 (JHU ref. 3188) A murine hybridoma cell line that secretes a monoclonal antibody (IgG1, k) against hum CD63. More...   Monoclonal antibodies against HIV and SIV co-receptors: Chemokine receptors CXCR4 and CCR5. (JHU ref. 3243) These monoclonal antibodies are specific for the chemokine receptors CXCR4 and CCR5, which mediate entry of HIV and SIV into susceptible cells. More...   JSC1 (JHU ref. 4349) This primary effusion lymphoma (PEL) cell line was established from lymphomatous peritoneal effusion ... More...   Molecular Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA (JHU ref. 4399) The invention provides molecular switches which couple external signals to functionality and to methods ... More...   A method to detect point mutations for diagnosis of human diseases (JHU ref. C04354) In cancer and other human diseases, single-base mutations have an important role and can be used as ... More...   Mixing Cell for Microcalorimeters (JHU ref. JHU Ref. 1180) The present invention relates to a device and method for measuring the heat of reaction resulting from ... More...   Polarization Lens (JHU ref. JHU Ref. 1205) The present invention pertains to a polarization viewer. The polarization viewer comprises a mechanism ... More...   293 EcR Sh Cell Line (JHU ref. 4408) Cell line for ecdysone-inducible expression of Shh. More...   R-3327-AT6.3 (JHU ref. 4365) Highly metastatic prostate cancer cell line which will grow both in vitro and in vivo More...   A Transgenic Mouse Line Expressing Green Fluorescent Protein in Cells Containing Endogenous Notch Pathway Activation (JHU ref. 4338) The TNR1 mouse line (Transgenic Notch Reporter) contains exogenous DNA stably integrated into the genome. ... More...   Antibody to Human DNA Methyltransferase 1 (JHU ref. 4328) We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human ... More...   Cell Lines with Targeted Deletions of SMAD4 (JHU ref. 4311) Creation of cell lines in which the SMAD4 genes have been disrupted by targeted homologous interation. More...   Human Cancer Cell Lines Deficient in the CDC4 Gene (JHU ref. 4300) To assess the role of CDC4 in genetic instability, we generated cells that lack functional CDC4 genes. ... More...   Human Cancer Cell Line Deficient in the BLM Gene (JHU ref. 4297) To assess the role of BLM in genetic instability, we generated cells that lack functional BLM genes. ... More...   Bungarotoxin Binding Site (BBS)-tagging of Proteins (JHU ref. 4270) A novel approach to tag proteins using a minimal bungarotoxin binding site (BBS-tag). In this method ... More...   Functionalized alpha 7 Nicotinic Receptor Ligands for Imaging  (JHU ref. 4269) JHU researchers have synthesized a variety of new radiopharmaceuticals for imaging the a7 subtype of ... More...   Method for finding mutations caused by the insertion of repeated DNAs (JHU ref. 4260) Retrotransposons are very abundant mobile components of the human genome. They can move from one site ... More...   Library of Genotypically Defined Mycobacterium tuberculosis Mutants. (JHU ref. C04275) Tuberculosis is a serious and lethal infectious disease that exists worldwide. There is a recognized ... More...   Human Protein Reference Database (JHU ref. 4236) Human Protein Reference Database (HPRD) is a database of human proteins that includes almost all proteins ... More...   Multi-color in vitro Translation (JHU ref. 4237) In vitro translation is a widely used tool for both analytical and preparative purposes. For analytical ... More...   Synthetic Mammalian Retrotransposon Gene (JHU ref. 4212) Retrotransposons are infectious pieces of DNA that can insert themselves (a process referred to as retrotransposition) ... More...   Adriamycin-resistant carbonyl reductase-1 knock out mice (JHU ref. 4211) The cancer treatment drug doxorubicin (brand name adriamycin) is very effective against tumors, but ... More...   Genetically engineered “Down syndrome” mice (JHU ref. 4210) We used chromosome engineering to create mice that have the extra genes in a “critical region” proposed ... More...   Cell Lines Expressing APC in an Inducible Manner  (JHU ref. 4202) JHU scientists have created an inducible expression system for APC in HT-29 colorectal carcinoma cells. ... More...   Rat 1a-myc (JHU ref. 4170) Rat 1a-myc is a human MYC oncogene transformed Rat 1a fibroblast cell line. More...   PUMA Mediates the Apoptotic Response to p53 (JHU ref. 4140) The p53 pathway is inactivated in the great majority of human cancers. Of the many physiologic effects ... More...   DNA methyltransferase gene Knock-out  (JHU ref. 4113) Cell lines with disruptions of various DNA methyltransferase genes have been created. More...   Disulfide Constrained Peptides for Targeting the Prostate Specific Membrane Antigen (JHU ref. 4111) Utilizing a standard phage display methodology, we have screened a hepta-peptide disulfide bridge constrained ... More...   A Molecular Mechanism for Action of Immunophilins and a Method to Identify Novel Pharmaceuticals (JHU ref. 4091) The immunophilins are a family of proteins that are functionally related by their rotamase activity ... More...   Cell Lines For Evaluation of 'Beta'-Catenin Function (JHU ref. 4055) Mutation in the beta-catenin/APC pathway are responsible for over 90% of all colon cancers in humans. ... More...   Microarray Data Assembler: A Program for Assembling Microarray Data (JHU ref. 4068) Large volumes of microarray data are generated and deposited in public databases. Most of these data ... More...   Use of Immunophilin Ligands to Prevent Neurotoxicity Associated with Use of Nucleoside Analogue Reverse Transcriptase Inhibitors (JHU ref. 4052) We developed an in vitro model of a painful neuropathy that develops in HIV infected patients who are ... More...   Specific Ablation of STAT3(beta) Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery From Endotoxic Shock (JHU ref. 4025) Stat3 is one of seven mammalian signal transducer and activator of transcription molecules that are ... More...   Prostate Cancer Cells Derived from Familial Prostate Cancer Tumor and Methods of Use (JHU ref. 3946) A cell line has been generated from a culture of prostate epithelial cells taken from a prostate cancer ... More...   Simultaneous DNA Sequencing Technique (SimulSeq) and Combined PCR/sequencing (AmpliSeq) (JHU ref. 3935) We report two novel methods for DNA sequencing. AmpliSeq permits combined PCR and cycle sequencing ... More...   Molecular Switches and Methods for Making and Using the Same  (JHU ref. 1706) The invention provides molecular switches which couple external signals to functionality and to methods ... More...   Disruption of p53 in Human Cancer Cells Alters the Responses to Therapeutic Agents (JHU ref. 3920) p53 knockout in human colorectal cancer cell line HCT116. Details are described in the paper by Bunz et al., 1999 (see below). More...   A 14-3-3Sigma knockout in human colorectal cancer cells lines HCT116 (JHU ref. 3919) 14-3-3Sigma knockout in human colorectal cancer cell line HCT116. Details are described in the paper ... More...   Carcinogen-specific Induction of Genetic Instability (JHU ref. 3921) The researchers created two H3 colorectal cancer cell lines. One cell line has chromosomal instability ... More...   O2-Benzyl-substituted Diazeniumdiolates that Release Nitric Oxide at Controlled Rates Upon Photolysis (JHU ref. 1703) Nitric oxide (NO) is a critically important bioregulator, involved in a wide range of processes including ... More...   Inhibition of Retroelement Replication With Divalent Cations (JHU ref. 3899) AIDS is a devastating disease caused by the HIV-1 virus. Happily, there are now highly active antiviral ... More...   Rhesus macaque chemokine receptor CCR8 cDNA. (JHU ref. 3890) Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors with or without ... More...   Beta-Secretase (BACE1) Knockout Fibroblast Cells (JHU ref. 3882) We have developed BACE1 knockout cells to further facilitate our understanding of physiological consequences ... More...   JHU-31 Rat Prostate R3327-AT-3.1 Tumor Cell Line (JHU ref. 3849) AT-3 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 ... More...   JHU-30 Rat Prostate R3327-AT-2.1 Tumor Cell Line (JHU ref. 3854) AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 ... More...   R-3327-MAT-Lu (JHU ref. 3852) This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the ... More...   JHU-29 Rat Prostate R3327-AT-1 Tumor Cell Line (JHU ref. 3848) AT-1 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 ... More...   R-3327 G (JHU ref. 3850) The in vitro cell line R-3327-G was derived from the parental R3327 tumor discovered by W.F. Dunning ... More...   R-3327 MAT-LyLu (JHU ref. 3853) This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the ... More...   Somatic cell hybrid cell line that identifies metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11 (JHU ref. 3847) Somatic cell hybrids created from highly metastatic rat prostatic cancer cells and human chromosome ... More...   Gene Identification Through Nonsense-Mediated Decay Inhibition (JHU ref. 3842) Johns Hopkins University researchers report a strategy, termed Gene Identification by Nonsense-Mediated ... More...   MoPrP. Xho Vector (JHU ref. 3840) This plasmid expression vector was developed to direct the expression of foreign genes in the brains ... More...   Three Cube FRET Method (3 to the power of 3 -FRET) for Detecting Fluorescence Energy Transfer Between Cyan Fluorescent Protein (CFP) and Yellow Fluorescent Protein (YFP) (JHU ref. 3837) Researchers at Johns Hopkins University (JHU) have developed a novel technology, termed three-cube fluorescence ... More...   Genetic Disruption of PPAR(delta) Decreases Tumorigenicity of Human Colon Cancer Cells (JHU ref. 3819) Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are involved ... More...   Inhibition of Apoptosis Process and Improvement of Cell Performance (JHU ref. 1637) The present invention relates to preventing or delaying programmed cell death by expressing one or more ... More...   Beta - Secretase (BACE1) Knockout Mice (JHU ref. 3774) Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta ... More...   CTD110.6 monoclonal antibody (JHU ref. 3770) O-linked N-acetylglucosamine (O-GlcNAc) is a newly described but ubiquitous dynamic modification of ... More...   Use of Fluorescence Resonance Energy Transfer to Directly Monitor the Receptor-Mediated Activation of Heterotrimeric G-proteins in Living Cells (JHU ref. 3757) Techniques to visualize heterotrimeric G-protein signaling in cells has not proven effective thus far. ... More...   PICK1 Antibody and GluR2 Phospho-specific Antibody (JHU ref. 3753) Antibodies to analyze the levels of the PICK1 protein and the phosphorylation of Ser880 of the AMPA receptor GluR2 subunit. More...   Recombinant Ehrlichia Phagocytophila Major Surface Protein (MSP) From Clone p20H13  (JHU ref. 3727) Recombinant E. phagocytophilia MSP is a major immunodominant protein antigen derived from the human ... More...   Recombinant Ehrlichia Phagocytophilia AnkA Protein (EPANK1 Protein) from Clone pHGE-D (JHU ref. 3726) Recombinant E. phagocytophilia MSP is a major immunodominant protein antigen derived from the human ... More...   CAIN Antibody (JHU ref. 3713) A novel protein which is a calcineurin inhibitor (CAIN) has been identified, cloned, and characterized. More...   LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses (JHU ref. 3712) JHU researchers constructed a reporter cell line, derived from human CEMx174 cells, that can be used ... More...   GRASP1 (Grip Associated Protein) (JHU ref. 3653) The synaptic targeting of glutamate receptors plays a critical role in the efficiency of synaptic transmission ... More...   Transgenic Mice Expressing a Truncated Mutant of Rat Cardiac Troponin (JHU ref. 3648) Stunned myocardium is a reversible contractile failure secondary to coronary artery disease. It has ... More...   A Human Nicotinic Acetylcholine Receptor Expressed in the Tonsil and Inner-Ear (JHU ref. 3624) Researchers at Johns Hopkins University have recently cloned a novel, human cDNA expressed in both the ... More...   Anti-HIF-1B Antibodies (JHU ref. 3592) Polyclonal antibodies were raised in rabbits and monoclonal antibodies were raised in mice that recognize hypoxia-inducible factor-1ß. More...   Glutamate Transporter Associated Proteins (JHU ref. 3572) Glutamate transport is an essential component of central glutamatergic neurotransmission. Excitatory ... More...   Fusion of Heat Shock Protein 70 to Antigens Enhances the Potency of DNA Vaccines (JHU ref. 3570) Increasing evidence has suggested that CD8+ T cell mediated immune responses are important in controlling ... More...   Development of Screening Assays for Selecting Agents that Promote the Proper Folding of Delta F508 CFTR (JHU ref. 3551) The ability of a protein to fold into a unique, functional, three dimensional structure in vivo is dependent ... More...   Synphilin-1, a Protein which Associates with Alpha-Synuclein and Promotes the Formation of Cytostolic Inclusions (JHU ref. 3531) Complementary DNA encoding the neural protein “synphilin-1” was cloned via the protein’s interaction ... More...   Narp is a Synaptogenic Factor for Excitatory Glutamate Receptors (JHU ref. 3526) A novel neuronal cell growth factor, neuronal-activity regulated pentraxin or NARP and its encoding ... More...   Structure and Alternative Splicing of the Gene Encoding a1I, a Human Brain T Calcium Channel a1 submit (JHU ref. 3528) The structure of genes encoding human brain T-type calcium channels subunits Alpha 1I and Alpha1G were ... More...   TC-1 (Po) (JHU ref. 3436) This cell line "was developed to circumvent the confounding issue of negatively selecting nonessential ... More...   Anti Qa-1 Monoclonal Antibodies (JHU ref. 3422) Dr. Soloski's laboratory has been interested for a number of years in the function of non-polymorphic ... More...   Method for Generating Hypermutable Organisms (JHU ref. 3351) The inventors have discovered a method for developing hypermutable cells and animals by taking advantage ... More...   14-3-3 Mediates a p53-Induced G2 Arrest (JHU ref. 3338) Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in G1 ... More...   Tn7 Transposition Derivatives (JHU ref. 3223) The invention is specifically directed to efficient, random, simple insertion of a transposon or derivative ... More...   Targeted Expression of Growth Factors and Trophic Factors in the Retina and Retinal Pigmented Epithelium (JHU ref. 3121) The expression of vascular endothelial growth factor (VEGF) has been found to be associated with ocular ... More...   Use of Recombinant Bacteriophages to Monitor Ion Channel Receptor Expression im Mammalian Cells (JHU ref. 3116) The present invention concerns a novel method for detecting cell surface proteins utilizing a modified ... More...   RL12, RL1, RL13, RL2 Monoclonal Antibodies (JHU ref. 3099) RL1, mouse monoclonal IgM that recognizes a group of eight O-linked glycoproteins of the nuclear pore ... More...   Human Blood Samples that Contain the Human Granulocytic Ehrlichia (JHU ref. 3088) Blood and serum samples from patients with corroborated HGE or HME. Blood samples contain antigens and ... More...   Plasmids Encoding the 16S rRNA Genes of Ehrlichia Equi and Human Granulocytic Ehrlichia (JHU ref. 3087) Cloned partial 16S rRNA genes (rrs) of several strains of Anaplasma phagocytophila (human granulocytic ehrlichiosis [HGE] agent). More...   Novel Oxalate/Formate Exchange Protein (JHU ref. 3048) A DNA sequence encoding a transport protein responsible for the physical movement of oxalate and formate ... More...   Bacteriophage Genomic Clones MGT-1, MGT-7B, MGT-7D (JHU ref. 9978) Lambda clones which incorporate either a genomic insert or a cDNA insert that contains the complete ... More...   Cell Line Overexpressing DNA Methyltransferase (JHU ref. 9971) Abnormal regional increases in DNA methylation, which have potential for causing gene inactivation and ... More...   A Mouse Model of Hemophilia A (JHU ref. 9948) A transgenic mouse deficient in blood factor VIII has been developed. This mouse serves as a model of human hemophilia. More...   Narp is a Synaptogenic Factor for Excitatory Glutamate Receptors (JHU Ref. DM-3526 & 9943) (JHU ref. 9943) A novel neuronal cell growth factor, neuronal-activity regulated pentraxin or NARP and its encoding ... More...   Aquaporin 5 (JHU ref. 9918) A transmembrane water channel protein is isolated in highly purified form from human erythrocytes. An ... More...   Glutamate Receptor Antibodies (JHU ref. 9832) Sub-unit specific anti-peptide antibodies which have been developed against the predicted amino acid ... More...   Reverse Two Hybrid Systems (JHU ref. 9784) Methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or ... More...   Cell Adhesion Assay (JHU ref. 9770) A rapid assay for cell adhesion, cell invasion and chemotaxis. Assay has been improved using 96-well ... More...   Primer Island Transposition: Ty1 integrase-mediated insertion of an artificial transposon into plasmids for the purpose of creating "primer islands" to map and sequence DNA  (JHU ref. 9749) We have developed efficient methods of creating artificial transposons and inserting these transposons ... More...   Microencapsulation of Living Cells By Biopolymers (JHU ref. C09716) The invention relates to living cells encapsulated in a membrane. The membrane is a complex formed by ... More...   Recombinationally-targeted cloning in Saccharomyces cerevisiae artificial chromosomes (JHU ref. 9690) Homologous recombination techniques are used to produce yeast artificial chromosomes (YAC) containing ... More...   Karyoplasmic Interaction Selection Strategy (JHU ref. 9666) Karyoplasmic Interaction Selection Strategy is a system of plasmids that assays protein-protein interactions ... More...   Mutagenesis with Trinucleotides (JHU ref. 9472) A new technique for generating mixtures of oligonucleotides in a single automated synthesis is provided. ... More...   Monoclonal Antibody  (JHU ref. 9320) A rat hybridoma producing a high-affinity IgG2a monoclonal antibody (B3B4) directed against the murine ... More...   Carbohydrate-Specific Cell Adhesion Directly to Glycosphingolipids Separated on Thin-layer Chromatography Plates (JHU ref. 2313) An apparatus is provided for determining binding of mammalian cells to carbohydrates on a chromatographic ... More...   A Cell Line with Targeted Deletions of both Bax and p21 (JHU ref. 4312) A Bax and p21 knock out cell line in human colorectal cancer cells. Details are described in the papers ... More...   High-efficiency integration of transgenes into bacterial chromosomes without a drug marker (JHU ref. 4731) This invention allows the insertion of foreign DNA into an innocuous site in the bacterial chromosome ... More...   HIGH-THROUGHPUT METHOD FOR DETECTING 14-3-3 BINDING TO TARGET MOLECULES (JHU ref. 4766) 14-3-3 proteins are a family of conserved regulatory molecules that have the ability to bind a multitude ... More...   NOVEL Trk KINASE KNOCKOUT MICE TO STUDY NEUROTROPHIN SIGNALING (JHU ref. 4844) Neurotrophins are a family of molecules that encourage survival of nervous tissue by secreting factors ... More...   MODEL NEUROPILIN-1 KNOCKOUT MOUSE (JHU ref. 4679) Neuropilin-1 (Npn-1) is a receptor that binds ligands from structurally distinct families like semaphorins ... More...   NOVEL RETINOID-INDUCIBLE GENE INVOLVED IN SPINAL MOTOR NEURON DIFFERENTIATION (JHU ref. 4585) During neural development, regulation of cell-cycle and differentiation is essential for cell-fate specification, ... More...   IMMEDIATE EARLY GENE THAT PLAYS A ROLE IN EARLY-ONSET FAMILIAL ALZHEIMER’S DISEASE (JHU ref. 4579) Presenilins are polytopic transmembrane (TM) proteins. Mutations in presenilins are associated with ... More...   ROLE OF EXTRA-CELLULAR MATRIX PROTEINS AS INFLAMMATION MODULATORs (JHU ref. 4946) Many biological processes affect the host’s ability to recognize pathogens, mount an innate immune response ... More...   METHOD TO IMPROVE CONTRACTILE FUNCTION AND METABOLISM IN HEART FAILURE (JHU ref. 4969) Cardiac contraction generates the pumping action of the heart, while chemical energy derived from heart ... More...   Embryonic Stem Cells from Animal Models of Motor Neuron Diseases (JHU ref. 4971) Progress in the development of therapies for motor neuron diseases has been hampered by the lack of ... More...   A Novel Regulator of Cytochrome P450 Enzymes (JHU ref. 5023) This invention describes the discovery of a novel gene whose gene product binds to cytochrome P450 enzymes ... More...   Diagnostic screening for disorders of the ER-to-Golgi trafficking (JHU ref. 4960) This technology describes Cranio-lenticulo-sutural dysplasia (CLSD) as a novel autosomal recessive syndrome, ... More...             Home | Legal | Site Credits